Evidence map›Paper›PMID 40148329›Full record

ArticleNature communications2025

Scaling-up molecular logic to meso-systems via self-assembly.

Ze-Qing Chen, Brian Daly, Chao-Yi Yao, Hannah S N Crory, Yikai Xu, Ziwei Ye, H Q Nimal Gunaratne, Ayumi Kimura, Seiichi Uchiyama, Steven E J Bell and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ze-Qing ChenSchool of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, Northern Ireland, UK.ORCID http://orcid.org/0009-0009-8026-5730
Brian DalySchool of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, Northern Ireland, UK.
Chao-Yi YaoSchool of Chemistry and Chemical Engineering, Central South University, Yuelu District, Changsha, Hunan Province, 410006, China.
Hannah S N CrorySchool of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, Northern Ireland, UK.
Yikai XuSchool of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, Northern Ireland, UK.ORCID http://orcid.org/0000-0003-3881-8871
Ziwei YeSchool of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, Northern Ireland, UK.ORCID http://orcid.org/0000-0001-8761-8265
H Q Nimal GunaratneSchool of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, Northern Ireland, UK.
Ayumi KimuraInstitute of Engineering Innovation, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-8656, Japan.ORCID http://orcid.org/0009-0002-9228-994X
Seiichi UchiyamaGraduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.ORCID http://orcid.org/0000-0003-4463-1034
Steven E J BellSchool of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, Northern Ireland, UK.ORCID http://orcid.org/0000-0003-3767-8985
Eric V AnslynSchool of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, Northern Ireland, UK.ORCID http://orcid.org/0000-0002-5137-8797
A Prasanna de SilvaSchool of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, Northern Ireland, UK. a.desilva@qub.ac.uk.ORCID http://orcid.org/0000-0003-4914-1333

Funding

Leverhulme Trust RPG-2019-314
6 · The paper itself

Abstract

Due to the small size and biocompatibility of molecules, molecular logic-based computation is a gateway to the informational basis of life processes. Logic-based computation operates widely with discrete molecules of up to nanometric sizes. The contribution of molecule-based bulk materials of milli/centimetric size to the field has begun in more recent years. However, artificial molecule-based meso-scale systems which intrinsically perform logic operations are very rare. Here, we show that self-assembled systems consisting of cyclophane octacarboxylates and a cationic surfactant can perform such functions, where a membrane itself behaves as a Reset-Set Flip-Flop which is integrated with 7 more logic elements. Now that molecular logic-based computation operates across a wide range of contiguous size-scales, the way opens for its general use in information processing aspects of biology and synthetic biology.

Identifiers

PMID40148329
PMCPMC11950191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.