Evidence map›Paper›PMID 40148078›Full record

ReviewRenal failure2025

Treatment of nephrotic syndrome with anti-CD20 therapies in pregnancy: a case series and review of the literature.

Pierre-Alexis Gauci, Marion Cremoni, Jérôme Delotte, Flavia Vocila, Vincent L M Esnault, Barbara Seitz-Polski, Maxime Teisseyre

Abstract readCase ReportsReview
In one paragraph

Review in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pierre-Alexis GauciDepartment of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Nice University Hospital, Université Côte d'Azur, Nice, France.
Marion CremoniInstitut de Recherche sur le Cancer et Vieillissement UMR7284 CNRS INSERM U1081, Université Côte d'Azur, Nice, France.
Jérôme DelotteDepartment of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Nice University Hospital, Université Côte d'Azur, Nice, France.
Flavia VocilaDepartment of Nephrology and Dialysis, Cannes Hospital, Cannes, France.
Vincent L M EsnaultReference Center for Rare Diseases Idiopathic Nephrotic Syndrome and Membranous Nephropathy, Nice University Hospital, Université Côte d'Azur, Nice, France.
Barbara Seitz-PolskiInstitut de Recherche sur le Cancer et Vieillissement UMR7284 CNRS INSERM U1081, Université Côte d'Azur, Nice, France.
Maxime TeisseyreInstitut de Recherche sur le Cancer et Vieillissement UMR7284 CNRS INSERM U1081, Université Côte d'Azur, Nice, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) are autoimmune kidney diseases and the most common causes of nephrotic syndrome. Anti-CD20 monoclonal antibodies are now recommended as first-line therapy for MN. Anti-CD20 monoclonal antibodies are also effective in steroid-dependent or frequently relapsing nephrotic syndrome associated with MCD or FSGS. Many women eligible for these treatments are of childbearing age. The impact of anti-CD20 therapies on pregnancy and fetal outcomes remains uncertain, particularly in glomerular diseases. We describe three cases of patients with glomerular disease treated with anti-CD20 therapies in the context of pregnancy and review the literature.

Indexed as

Antigens, CD20Nephrotic SyndromePregnancy ComplicationsRituximabAdultFemaleGlomerulosclerosis, Focal SegmentalHumansNephrosis, LipoidPregnancyAntigens, CD20Rituximabauto-immunitynephrotic syndromeobinutuzumabPregnancyrituximab

Identifiers

PMID40148078
PMCPMC11951322

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.