Evidence map›Paper›PMID 40147827›Full record

ArticleCancer research and treatment2026

Association of Physical Activity with Dementia Risk in Cancer Survivors: A Korean Nationwide Cohort Study.

Su Kyoung Lee, Minji Han, Sangwoo Park, Sun Jae Park, Jihun Song, Hye Jun Kim, Jaewon Kim, Hyeokjong Lee, Hyun-Young Shin, Kyae Hyung Kim and 1 more

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Article in Cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Su Kyoung LeeInstitute of Health and Environment Graduate School of Public Health, Seoul National University, Seoul, Korea.
Minji HanDepartment of Health Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
Sangwoo ParkDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Sun Jae ParkDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Jihun SongDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Hye Jun KimDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Jaewon KimDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Hyeokjong LeeDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Hyun-Young ShinDepartment of Family Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kyae Hyung KimDepartment of Family Medicine, Seoul National University Hospital, Seoul, Korea.
Sang Min ParkDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.

Funding

Ministry of Education RS-2023-00244084National Research Foundation of Korea 2021R1F1A1063346
6 · The paper itself

Abstract

purposeThis study aimed to investigate the impact of physical activity on dementia risk among cancer survivors in South Korea. MATERIALS AND

methodsThis retrospective, population-based cohort study included 344,152 cancer survivors identified from the National Health Insurance Service database in South Korea. The mean follow-up time was 5.81 years. Different levels of physical activity post-cancer diagnosis, ranging from inactive to highly active, were assessed. The primary outcome was the incidence of overall dementia, Alzheimer's disease, and vascular dementia. Secondary outcomes included dementia risk stratified by cancer type and treatment (chemotherapy and radiation).

resultsOf the total participants, 24,363 (7.08%) developed dementia. The risk of overall dementia decreased sequentially across the exercise groups compared to the inactive group: insufficiently active (adjusted hazard ratio [HR], 0.89; 95% confidence interval [CI], 0.86 to 0.92), active (adjusted HR, 0.85; 95% CI, 0.83 to 0.88), and highly active (adjusted HR, 0.79; 95% CI, 0.76 to 0.82). This inverse relationship between exercise and dementia risk was statistically significant across various cancer types and was consistent regardless of age, comorbidities, and whether or not excluding the first 1, 2 years.

conclusionAmong cancer survivors in South Korea, increased physical activity post-diagnosis was associated with a significantly lower risk of dementia. These findings underscore the importance of promoting physical activity in cancer survivors for cognitive health.

Indexed as

Cancer SurvivorsDementiaExerciseNeoplasmsAdultAgedCohort StudiesFemaleHumansIncidenceMaleMiddle AgedRepublic of KoreaRetrospective StudiesRisk FactorsAlzheimer’s diseaseCancer survivorsChemotherapyDementiaPhysical activityRepublic of KoreaVascular dementia

Identifiers

PMID40147827
PMCPMC12800954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.