Evidence map›Paper›PMID 40147772›Full record

ArticleThe Journal of biological chemistry2025

Role of SIRT3 in the regulation of Gadd45α expression and DNA repair in β-cells.

Aaron Naatz, Kelsey S Bohl, Rachel A Jones Lipinski, Joshua A Nord, Alyssa L Gehant, Polly A Hansen, Brian C Smith, John A Corbett

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aaron NaatzDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Kelsey S BohlDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Rachel A Jones LipinskiDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Joshua A NordDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Alyssa L GehantDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Polly A HansenDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Brian C SmithDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
John A CorbettDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address: jcorbett@mcw.edu.

Funding

BIOCHEMICAL MECHANISM OF BETA-CELL DESTRUCTIONR01DK052194 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CORBETT, JOHN A · 1998 to 2025
$8.8M
MECHANISMS OF VIRAL INDUCED BETA CELL DAMAGER01AI044458 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CORBETT, JOHN A · 1998 to 2024
$7.5M
Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
Biochemical mechanisms of beta cell protection through bromodomain inhibitionR01DK119359 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI Brian Christopher Smith · 2018 to 2026
$3.1M
Sirt6 NAD+-Dependent Protein Deacetylase Inhibition by Cysteine S-nitrosationF31DK117588 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI KALOUS, KELSEY SHEA · 2018 to 2020
$110k
NHLBI NIH HHS T32 HL134643NIAID NIH HHS R01 AI044458NIDDK NIH HHS F31 DK117588NIDDK NIH HHS R01 DK052194NIDDK NIH HHS R01 DK119359
6 · The paper itself

Abstract

In previous studies, we have shown that growth arrest and DNA damage (Gadd) 45α is required for the repair of nitric oxide-mediated DNA damage in β-cells. Gadd45α expression is stimulated by nitric oxide and requires forkhead box protein (Fox) O1 and NAD

Indexed as

Cell Cycle ProteinsDNA RepairGene Expression RegulationInsulin-Secreting CellsNuclear ProteinsSirtuin 3AcetylationAnimalsDNA DamageForkhead Box Protein O1Forkhead Transcription FactorsGADD45 ProteinsMaleMiceMitochondriaNitric OxideCell Cycle ProteinsForkhead Box Protein O1Forkhead Transcription FactorsFoxo1 protein, mouseGadd45a protein, ratGADD45 ProteinsNitric OxideNuclear ProteinsSirt1 protein, ratSIRT3 protein, ratSirtuin 1Sirtuin 3SirtuinsDNA repairGadd45αnitric oxideSirt3sirtuinβ-cell

Identifiers

PMID40147772
PMCPMC12051128

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.