Evidence map›Paper›PMID 40147739›Full record

ArticleNeurobiology of disease2025

Early life seizures chronically disrupt L-type voltage gated calcium channel regulation of mGluR mediated long term depression via interactions with protein phosphatase 2A.

Paul B Bernard, Anna M Castano, Olivia R Buonarati, Chad R Camp, Johannes W Hell, Tim A Benke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paul B BernardDepartments of Pediatrics, University of Colorado, School of Medicine, United States of America.
Anna M CastanoDepartments of Pediatrics, University of Colorado, School of Medicine, United States of America; Pharmacology, University of Colorado, School of Medicine, United States of America.
Olivia R BuonaratiPharmacology, University of Colorado, School of Medicine, United States of America; Department of Pharmacology, School of Medicine, University of California, Davis, CA, United States of America.
Chad R CampPharmacology, University of Colorado, School of Medicine, United States of America.
Johannes W HellDepartment of Pharmacology, School of Medicine, University of California, Davis, CA, United States of America.
Tim A BenkeDepartments of Pediatrics, University of Colorado, School of Medicine, United States of America; Pharmacology, University of Colorado, School of Medicine, United States of America; Neurology, University of Colorado, School of Medicine, United States of America; Otolaryngology, University of Colorado, School of Medicine, United States of America. Electronic address: tim.benke@cuanschutz.edu.

Funding

Institutional Training in Otolaryngology ResearchT32DC012280 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Yuri Agrawal, Sue C. Kinnamon · 2013 to 2026
$3.4M
Postsynaptic Signaling by Norepinephrine and cAMPR01NS123050 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2022 to 2026
$2.3M
Dysregulation of Cav1.2 by beta amyloid peptideRF1AG055357 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2022 to 2024
$1.7M
Molecular mechanisms linking early life seizures, autism and intellectual disabilR01NS076577 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BENKE, TIMOTHY A · 2011 to 2015
$1.6M
Exploratory determination of the role of L-type calcium channels in mediating abnormal plasticity and behavior after early life seizuresR21NS101288 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BENKE, TIMOTHY A · 2017 to 2018
$419k
MRP4 extrudes cAMP for localized regulation of calcium channel activityF31NS086226 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ASFAHA, OLIVIA RUTH · 2013 to 2015
$110k
NIA NIH HHS RF1 AG055357NIDCD NIH HHS T32 DC012280NINDS NIH HHS F31 NS086226NINDS NIH HHS R01 NS076577NINDS NIH HHS R01 NS123050NINDS NIH HHS R21 NS101288
6 · The paper itself

Abstract

We probed the dependence of metabotropic glutamate receptor dependent long-term depression (mGluR-LTD) on L-type voltage gated calcium channels (LTCCs). In prior work, we found that in a rat model of early life seizures (ELS), exaggerated mGluR-LTD was partly mediated by LTCCs and protein phosphatase 2A (PP2A). Here, we further investigated the interactive role of LTCCs, PP2A, and protein kinase A (PKA) in this same model. PP2Ac is known to bind Ca

Indexed as

Calcium Channels, L-TypeLong-Term Synaptic DepressionProtein Phosphatase 2Receptors, Metabotropic GlutamateSeizuresAnimalsCyclic AMP-Dependent Protein KinasesDisease Models, AnimalHippocampusMaleRatsRats, Sprague-DawleyCalcium Channels, L-TypeCyclic AMP-Dependent Protein KinasesProtein Phosphatase 2Receptors, Metabotropic GlutamateCa(V)1.2Early life seizureLong-term depressionL-type voltage gated Ca(2+) channelsMetabotropic glutamate receptorProtein phosphatase 2ASynaptic plasticity

Identifiers

PMID40147739
PMCPMC12039582

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.