Evidence map›Paper›PMID 40147570›Full record

ArticleRespiratory medicine2025

Platelet activation and COPD-related clinical and imaging characteristics: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study.

Carrie L Pistenmaa, Eric A Hoffman, Martin R Prince, Emlyn Hughes, Stephen Dashnaw, Christian M Lo Cascio, Elizabeth C Oelsner, Wei Shen, Yanping Sun, Hinrich Winther and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Carrie L PistenmaaColumbia University, New York, NY, USA; Brigham and Women's Hospital, Boston, MA, USA.
Eric A HoffmanUniversity of Iowa, Iowa City, IA, USA.
Martin R PrinceColumbia University, New York, NY, USA.
Emlyn HughesColumbia University, New York, NY, USA.
Stephen DashnawColumbia University, New York, NY, USA.
Christian M Lo CascioColumbia University, New York, NY, USA.
Elizabeth C OelsnerColumbia University, New York, NY, USA.
Wei ShenColumbia University, New York, NY, USA.
Yanping SunColumbia University, New York, NY, USA.
Hinrich WintherInstitute for Diagnostic and Interventional Radiology, Hannover Medical School, Germany; Member of the German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Germany.
Jens Vogel-ClaussenInstitute for Diagnostic and Interventional Radiology, Hannover Medical School, Germany; Member of the German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Germany.
Jim M WildUniversity of Sheffield, Sheffield, UK.
Russell P TracyUniversity of Vermont, Burlington, VT, USA.
R Graham BarrColumbia University, New York, NY, USA.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001873NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K23 HL141651NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NIDDK NIH HHS P30 DK026687NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

introductionThe pulmonary vasculature has been implicated in chronic obstructive pulmonary disease (COPD). Whether platelet activation is associated with COPD-related characteristics is unknown.

methodsThe Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study enrolled participants with 10+ pack-years with and without COPD from 2 cohort studies. Platelet activation was measured in platelet-free plasma as von Willebrand factor (vWF), beta-thromboglobulin (BTG) and platelet factor 4 (PF4). Phenotyping included spirometry, percent emphysema

resultsThe 116 with vWF were a mean age of 73.5 ± 7.3 years old, 60 % male, 58 % Non-Hispanic White, 28 % Black, 14 % Hispanic/Latino, 23 % smoked currently and 55 % had COPD. vWF was associated with lower FEV

conclusionsPlatelet activation was associated with measures of small airways disease and pulmonary microvascular perfusion in this sample of smokers with and without COPD.

Indexed as

AtherosclerosisPlatelet ActivationPulmonary Disease, Chronic ObstructiveAgedAged, 80 and overCase-Control StudiesFemaleForced Expiratory VolumeHumansLungMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesSmokingSpirometryvon Willebrand FactorCOPDImaging in COPDPlatelet activationSmall airways disease

Identifiers

PMID40147570
PMCPMC12164369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.