ArticleCell reports. Medicine2025
Inhibition of basal IL-6 activity promotes subcutaneous fat retention in humans during fasting and postprandial states.
Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04687540 (Meal-regulated Substrate Metabolism, Influence of Obesity and IL-6), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Meal-regulated Substrate Metabolism, Influence of Obesity and IL-6
Who cites it
12 citing papers in PubMed.
- Exerkines in precision management of metabolic diseases.Chinese medical journal · 2026Review
- Exerkine-Mediated Inter-Organ Crosstalk and Translational Perspectives in Metabolic Diseases.Current obesity reports · 2026Review
- Lipoprotein metabolism and inflammation in healthy young subjects - exploring the postprandial and postabsorptive phases following intake of a standardized meal.Atherosclerosis plus · 2026Article
- A Retrospective Case Series Reporting the Clinical Efficacy and Adverse Events of Oclacitinib Administration for Skin Disease in 238 Cats.Veterinary dermatology · 2026Article
- Association between body composition and bone mineral density in young and middle-aged adults.BMC endocrine disorders · 2026Article
- Differential associations of muscle and fat body composition profiles with inflammatory cytokines in preschool children: a cross-sectional study.Scientific reports · 2026Article
- Influence of Obesity and IL-6 on Human Postprandial Amino Acid and Protein Metabolism at Whole-body and Tissue Level.The Journal of clinical endocrinology and metabolism · 2026Article
- Exercise-modulated IL-6 in cancer cachexia: molecular mechanisms and therapeutic potential.Journal of translational medicine · 2026Review
- Unraveling the Obesogenic Mechanism of Bisphenol A Through Network Toxicology and Molecular Docking: Identification of Key Molecular Targets.International journal of molecular sciences · 2025Article
- GLP-1/GLP-1R axis: from metabolism (obesity and T2DM) to immunity.Open biology · 2025Review
- Long-term efficacy and safety of carbon dioxide (COAmerican journal of translational research · 2025Article
- Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-6 (IL-6) knockout mice and humans treated with IL-6 receptor blockade gain adipose tissue mass. This study investigates whether basal IL-6 activity (resting IL-6 levels) influences fat storage during fasting and postprandial states. Using stable-isotope tracer techniques and IL-6 receptor blockade with tocilizumab, we examine fat kinetics in humans. Blocking basal IL-6 activity reduces fasting whole-body lipolysis, decreases hormone-sensitive lipase (HSL) phosphorylation and fatty acid release in adipose tissue, and impairs postprandial fatty acid uptake in the leg. These results suggest diminished fatty acid uptake and oxidation in skeletal muscle, along with enhanced fatty acid entrapment in adipose tissue, which may account for the increased adiposity in the absence of IL-6 activity. Additionally, IL-6 blockade increases the escape of meal-derived fatty acids into the bloodstream. Whether this affects fatty acid storage and lipotoxicity in other tissues warrants further investigation. This study was registered at ClinicalTrials.gov (NCT04687540).
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