Evidence map›Paper›PMID 40147445›Full record

ArticleCell reports. Medicine2025

A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities.

Danilo Fiore, Luca Vincenzo Cappelli, Liu Zhaoqi, Nikita Kotlov, Maria Sorokina, Jude Phillip, Paul Zumbo, Liron Yoffe, Paola Ghione, Anqi Wang and 67 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

77 authors.

Danilo FiorePathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy; Institute for Experimental Endocrinology and Oncology, "G.Salvatore" IEOS, Consiglio Nazionale delle Ricerche (CNR), 80131 Naples, Italy.
Luca Vincenzo CappelliPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Liu ZhaoqiProgram for Mathematical Genomics, Department of Systems Biology, Department of Biomedical Informatics, Columbia University, New York, NY 10027 USA; China National Center for Bioinformation, Beijing, China; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
Nikita KotlovBostonGene Corporation, Waltham, MA 02453, USA.
Maria SorokinaBostonGene Corporation, Waltham, MA 02453, USA.
Jude PhillipDivision of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10065 US; Chemical and Biomolecular Engineering, Oncology, Sidney Kimmel Comprehensive Cancer Center, Core Member, Institute for Nanobiotechnology (INBT), Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Paul ZumboApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, US.
Liron YoffePathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA.
Paola GhioneDepartment of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Anqi WangProgram for Mathematical Genomics, Department of Systems Biology, Department of Biomedical Informatics, Columbia University, New York, NY 10027 USA.
Xueshuai HanProgram for Mathematical Genomics, Department of Systems Biology, Department of Biomedical Informatics, Columbia University, New York, NY 10027 USA; China National Center for Bioinformation, Beijing, China; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
Abigail TaylorPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
William ChiuPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Valentina FragliassoPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA; Laboratory of translational research, Azienda USL - IRCCS di Reggio Emilia, 42122 Reggio Emila, Italy.
Fabrizio TabboPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA; SC Oncologia ASL CN2 Alba Bra Ospedale Michele e Pietro Ferrero, 12060 Verduno, (CN), Italy.
Nahuel ZamponiDivision of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10065 US.
Nicolás Di SierviDivision of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10065 US.
Clarisse KayembePathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Giovanni MedicoPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Ruchi P PatelCenter for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Perelman Center for Advanced Medicine, SPE 8-112, Philadelphia, PA 19104, USA; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Marcello GaudianoPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Rodolfo MachiorlattiDepartment of Pathology, Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy.
Giuseppina AstonePathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Maria Teresa CacciapuotiPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Giorgia ZanettiPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Claudia PignataroDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Ruiz Arvin EricPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Sanjay PatelPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Francesca ZammarchiADC Therapeutics (UK) Limited, London W12 0BZ United Kingdom.
Claudio ZanettiniPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Lucio QueirozPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA.
Anastasia NikitinaBostonGene Corporation, Waltham, MA 02453, USA.
Olga KudryashovaBostonGene Corporation, Waltham, MA 02453, USA.
Anton KarelinBostonGene Corporation, Waltham, MA 02453, USA.
Daniil NikitinBostonGene Corporation, Waltham, MA 02453, USA.
Dmitry TychininBostonGene Corporation, Waltham, MA 02453, USA.
Ekaterina PostovalovaBostonGene Corporation, Waltham, MA 02453, USA.
Alexander BagaevBostonGene Corporation, Waltham, MA 02453, USA.
Viktor SvekolkinBostonGene Corporation, Waltham, MA 02453, USA.
Ekaterina BelovaBostonGene Corporation, Waltham, MA 02453, USA.
Katerina TikhonovaBostonGene Corporation, Waltham, MA 02453, USA.
Sandrine DegryseBostonGene Corporation, Waltham, MA 02453, USA.
Chengqi XuEnglander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA.
Domenico NoveroDivision of Pathological Anatomy, Quality and Safety of Diagnosis and Treatment, Città della Salute e della Scienza, 10126 Turin, Italy.
Maurilio PonzoniPathology Unit, San Raffaele Scientific Institute, Milan, Italy; Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, 20132 Milan, Italy.
Enrico TiacciInstitute of Hematology, University of Perugia, Ospedale S. Maria della Misericordia, S. Andrea delle Fratte, 06156 Perugia Italy.
Brunangelo FaliniInstitute of Hematology, University of Perugia, Ospedale S. Maria della Misericordia, S. Andrea delle Fratte, 06156 Perugia Italy.
Joo SongDepartment of Pathology, City of Hope Medical Center, Duarte, CA 91010, US.
Inna KhodosAntitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, US.
Elisa De StanchinaAntitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, US.
Gabriele MacariGenomeUp S.r.l., 00144 Rome, RM, Italy.
Luciana CafforioGenomeUp S.r.l., 00144 Rome, RM, Italy.
Simone GardiniGenomeUp S.r.l., 00144 Rome, RM, Italy.
Roberto PivaDepartment of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy; Medical Genetics Unit, Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.
Enzo MedicoDepartment of Oncology, University of Torino, Candiolo, TO, Italy; Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.
Samuel Y NgDepartment of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; National Cancer Institute, Bethesda, MD 20892, USA.
Allison MoskowitzDepartment of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Zachary EpsteinDepartment of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Andrew IntlekoferDepartment of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Dogan AhmedDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Wing C ChanDepartment of Pathology, City of Hope Medical Center, Duarte, CA 91010, US.
Peter MartinLymphoma Service, Weill Cornell Medical Center, New York, NY 10065, USA.
Jia RuanLymphoma Service, Weill Cornell Medical Center, New York, NY 10065, USA.
Francesco BertoniLymphoma Genomics, Institute of Oncology Research, Faculty of Biomedical Sciences, USI, 6500 Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, EOC,6500 Bellinzona, Switzerland.
Robin FoàDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Joshua D BrodyDepartment of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, US; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
David M WeinstockMerck Research Laboratories, Boston, MA 02115, USA.
Jaspreet OsanDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY 10065, USA.
Laura SantambrogioDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY 10065, USA.
Oliver ElementoEnglander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA.
Doron BetelDivision of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10065 US; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, US.
Wayne TamPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA; Division of Hematopathology, Northwell Health, New York, NY 11740, USA.
Marco RuellaCenter for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Perelman Center for Advanced Medicine, SPE 8-112, Philadelphia, PA 19104, USA; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
Leandro CerchiettiDivision of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10065 US.
Raul RabadanProgram for Mathematical Genomics, Department of Systems Biology, Department of Biomedical Informatics, Columbia University, New York, NY 10027 USA.
Steven HorwitzDepartment of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Giorgio InghiramiPathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: ggi9001@med.cornell.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Project 3: Combinatorial and gene-editing approaches to enhance the efficacy of CAR T cell therapy of multiple myeloma.P01CA214278 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Joseph Anthony Fraietta · 2017 to 2026
$26.8M
Physician Scientist Training in Cancer ResearchT32CA009172 · NCI · DANA-FARBER CANCER INSTITUTE · PI Jennifer R Brown, James A. DeCaprio · 1985 to 2026
$17.1M
HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1M
Project 4 Green-DavisP01CA272295 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Sanjay Shutish Patel · 2024 to 2026
$9.3M
Towards a quantitative understanding of tumor evolutionR35CA253126 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Raul Rabadan · 2021 to 2026
$5.6M
Biochemical and functional characterization of a novel anti-inflammatory biogenic amineR01AI169723 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI LAURA SANTAMBROGIO · 2023 to 2026
$2.9M
MODULATION OF CD5 SIGNALING TO ENHANCE ADOPTIVE T-CELL THERAPIES FOR CANCERR37CA262362 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Marco Ruella · 2022 to 2026
$2.6M
Selective B Cell Depletion Using Engineered T Cells As A Curative Treatment For Acquired Thrombotic Thrombocytopenic PurpuraR01HL178849 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Vijay Bhoj, Marco Ruella · 2025 to 2026
$1.6M
FDA HHS R01 FD008168NCI NIH HHS P01 CA214278NCI NIH HHS P01 CA272295NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA253126NCI NIH HHS R37 CA262362NCI NIH HHS T32 CA009172NHLBI NIH HHS R01 HL178849NHLBI NIH HHS T32 HL007439NIAID NIH HHS R01 AI169723
6 · The paper itself

Abstract

Peripheral T cell lymphomas (PTCLs) comprise heterogeneous malignancies with limited therapeutic options. To uncover targetable vulnerabilities, we generate a collection of PTCL patient-derived tumor xenografts (PDXs) retaining histomorphology and molecular donor-tumor features over serial xenografting. PDX demonstrates remarkable heterogeneity, complex intratumor architecture, and stepwise trajectories mimicking primary evolutions. Combining functional transcriptional stratification and multiparametric imaging, we identify four distinct PTCL microenvironment subtypes with prognostic value. Mechanistically, we discover a subset of PTCLs expressing Epstein-Barr virus-specific T cell receptors and uncover the capacity of cancer-associated fibroblasts of counteracting treatments. PDXs' pre-clinical testing captures individual vulnerabilities, mirrors donor patients' clinical responses, and defines effective patient-tailored treatments. Ultimately, we assess the efficacy of CD5KO- and CD30- Chimeric Antigen Receptor T Cells (CD5KO-CART and CD30_CART, respectively), demonstrating their therapeutic potential and the synergistic role of immune checkpoint inhibitors for PTCL treatment. This repository represents a resource for discovering and validating intrinsic and extrinsic factors and improving the selection of drugs/combinations and immune-based therapies.

Indexed as

Lymphoma, T-Cell, PeripheralAnimalsFemaleHerpesvirus 4, HumanHumansImmune Checkpoint InhibitorsMiceMice, Inbred NODTumor MicroenvironmentXenograft Model Antitumor AssaysImmune Checkpoint InhibitorsCAR-Tclonal evolutiondrug screeningsmicroenvironmentpatient-derived tumor xenograftsprecision medicinepre-clinical trialsrepositorystratificationT cell lymphoma

Identifiers

PMID40147445
PMCPMC12047492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.