Evidence map›Paper›PMID 40146857›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Cholesterol-dependent enzyme activity of human TSPO1.

Weihua Qiu, Thi Kim Hoang Trinh, Claudio Catalano, Akul Mehta, Umesh R Desai, Glen E Kellogg, Wayne A Hendrickson, Youzhong Guo

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Advances in native cell membrane nanoparticles system.Current opinion in structural biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Weihua QiuDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298-0540.
Thi Kim Hoang TrinhDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298-0540.ORCID 0000-0002-9906-5896
Claudio CatalanoDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298-0540.
Akul MehtaDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298-0540.
Umesh R DesaiDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298-0540.
Glen E KelloggDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298-0540.
Wayne A HendricksonDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.ORCID 0000-0003-1412-5747
Youzhong GuoDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298-0540.ORCID 0000-0001-7177-9603

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
Training (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1M
Proposal for an Administrative Supplement for Equipment Purchases for NIGMS Awardees NOT-GM-18-022R01GM107462 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENDRICKSON, WAYNE A. · 2014 to 2021
$3.6M
Proposal for an Administrative Supplement for Equipment Purchases for NIGMS Awardees NOT-GM-22-017R01GM132329 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI GUO, YOUZHONG · 2019 to 2022
$1.9M
HHS | NIH | Office of Extramural Research (OER) GM107462HHS | NIH | Office of Extramural Research (OER) GM116799HHS | NIH | Office of Extramural Research (OER) GM132329NCI NIH HHS P30 CA016059NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R01 GM107462NIGMS NIH HHS R01 GM132329
6 · The paper itself

Abstract

The amino acid sequence of the tryptophan-rich sensory proteins (TSPO) is substantially conserved throughout all kingdoms of life. Human mitochondrial TSPO1 (

Indexed as

CholesterolReceptors, GABAAmino Acid SequenceHumansMitochondriaProtoporphyrinsCholesterolprotoporphyrin IXProtoporphyrinsReceptors, GABATSPO protein, humanbilindigincholesterolNCMNprotoporphyrin IXTSPO

Identifiers

PMID40146857
PMCPMC12002307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.