Evidence map›Paper›PMID 40146739›Full record

Trial reportSexual health2025

A digital citizen science intervention to reduce HIV stigma and promote HIV testing: a randomized clinical trial among adolescents and young adults in Kazakhstan.

Alissa Davis, Laura Nyblade, Yihang Sun, Olga Balabekova, Sara E Landers, Denis Gryazev, Joseph D Tucker, Valera Gulyaev, Susan L Rosenthal, Karsten Lunze and 54 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Sexual health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

64 authors.

Alissa DavisSchool of Social Work, Columbia University, New York, NY, USA.
Laura NybladeRTI International, Washington, DC, USA.
Yihang SunSchool of Social Work, Columbia University, New York, NY, USA.
Olga BalabekovaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Sara E LandersSchool of Social Work, Columbia University, New York, NY, USA.
Denis GryazevGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Joseph D TuckerInstitute for Global Health and Infectious Diseases, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA; and Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Valera GulyaevGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Susan L RosenthalDepartment of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA; and Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Karsten LunzeSection of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston, MA, USA; and Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA.
Weiming TangInstitute for Global Health and Infectious Diseases, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Azamat KuskulovSchool of Social Work, Columbia University, New York, NY, USA.
Assel TerlikbayevaSchool of Social Work, Columbia University, New York, NY, USA; and Global Health Research Center of Central Asia, Almaty, Kazakhstan.
Sholpan PrimbetovaSchool of Social Work, Columbia University, New York, NY, USA; and Global Health Research Center of Central Asia, Almaty, Kazakhstan.
Mingway ChangSchool of Social Work, Columbia University, New York, NY, USA.
Alfiya Y DenebayevaAlmaty City AIDS Center, Almaty, Kazakhstan.
Aikerim Utegulovna AkhmetovaAlmaty City AIDS Center, Almaty, Kazakhstan.
Ainur AbsemetovaNational Volunteer Network, Almaty, Kazakhstan.
Sholpan KarzhaubayevaAlmaty City Center for Human Reproduction, Youth and Family Health Department, Almaty, Kazakhstan.
Sairankul KassymbekovaKazakh Scientific Center of Dermatology and Infectious Diseases, Almaty, Kazakhstan.
Marina MaximovaKazakh Scientific Center of Dermatology and Infectious Diseases, Almaty, Kazakhstan.
Zhannat MussinaKazakh Scientific Center of Dermatology and Infectious Diseases, Almaty, Kazakhstan.
Gulnar BekenovaKazakhstan Association for Sexual and Reproductive Health, Almaty, Kazakhstan.
Zhamilya NugmanovaAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Zhanna KalmatayevaAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Ludmila PolyakovaTeenergizer, Almaty, Kazakhstan.
Zhanneta Kanaevna Zhazykbaeva'Protection of Children from AIDS' Charitable Public Foundation, Shymkent, Kazakhstan.
Vitaliy VinogradovGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Amir ShaikezhanovGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Meruyert DarishevaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Bella OrynbetovaInternews, Almaty, Kazakhstan.
Elena NorakidzeNarxoz University, Almaty, Kazakhstan.
Mashirov KozhakhmetShymkent City AIDS Center, Shymkent, Kazakhstan.
Akbota TolegenovaNazarbayev University, Astana, Kazakhstan.
Aknur ImadilldaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Dariga SatkhozhinaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Alikhan KartamyssovGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Zhamilya KanievaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Albina AleshinaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Olzhas MakhanGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Aida MuravyovaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Adema RahimzanovaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Arman DuisenbayevGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Zhanerke TursynbekGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Nurgazy DiasGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Malika BekenGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Miras MurzakhanGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Zhandos Ali BrownGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Daniyal MaitekovGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Artur LiGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Sandizaira MergenGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Dautali MergenovGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Amirali KuanyshGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Anuar RakhimbekovGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Yenlik BaisbayGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Alibek AruzhanGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Zhasmina KozhambetGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Denis GrebenchishikovGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Dmitriy BekkerGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Sultan KozhamberdievGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Dauren SalykovGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Madina SagimbayevaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Kamila YussupovaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Gaukhar MergenovaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.

Funding

Mentoring Multidisciplinary Global HIV Patient-Oriented ResearchK24AI143471 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph David Tucker · 2019 to 2026
$1.4M
A couple-based antiretroviral therapy adherence intervention for people who inject drugs in KazakhstanK01DA044853 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DAVIS, ALISSA · 2018 to 2022
$903k
Reducing HIV Stigma to Increase HIV Testing among Adolescents and Young Adults in Kazakhstan Using a Crowdsourcing ApproachR21TW012017 · FIC · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DAVIS, ALISSA, MERGENOVA, GAUKHAR · 2021 to 2022
$478k
FIC NIH HHS R21 TW012017NIAID NIH HHS K24 AI143471NIDA NIH HHS K01 DA044853NIDA NIH HHS L30 DA049137
6 · The paper itself

Abstract

Background Kazakhstan has a high HIV incidence among adolescents and young adults (AYA), and high HIV stigma contributing to low HIV testing uptake. We examined whether an AYA-developed digital crowdsourced intervention reduced HIV stigma compared with conventional public health materials among AYA in Almaty, Kazakhstan. Methods A total of 216 AYA (females:116/males:110) aged 16-24 years were recruited to the online study cohort and randomized 1:1 to the intervention or control arm. AYA were exposed to the crowdsourced intervention or control materials once a week for 5weeks, with equivalent exposures between arms. Outcomes included a total HIV stigma score assessed at baseline, immediately post-intervention and 2months post-intervention from January to August 2023. We conducted multilevel mixed models to compare changes over time by arm and sex. Results AYA in the intervention arm had significantly lower HIV testing stigma 2months post-intervention (adjusted mean change (AMC): -0.73 (-1.07, -0.39)) than AYA in the control arm (AMC: -0.06 (-0.42, 0.30); P =0.032). Female AYA in the intervention arm had significantly lower total HIV stigma immediately post-intervention (AMC: -4.91 (-7.25, -2.58)) and 2months post-intervention (AMC: -5.16 (-7.48, -2.84)) than females in the control arm (immediately post-intervention AMC: -0.03 (-2.63, 2.57) and 2-months post-intervention AMC: -0.07 (-2.70, 2.56); P =0.012, P =0.012). Conclusions The AYA-developed crowdsourced intervention decreased HIV testing stigma, although this effect was moderated by sex, and decreased total HIV stigma among female AYA. Crowdsourced interventions may be a promising way to engage communities to develop interventions to decrease HIV stigma.

Indexed as

CrowdsourcingHIV InfectionsHIV TestingSocial StigmaAdolescentFemaleHumansKazakhstanMaleYoung Adult

Identifiers

PMID40146739
PMCPMC12693062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.