ArticlePreventing chronic disease2025
Two Modeling Strategies in Analyzing Clustered Time-to-Event Data: the Strong Heart Family Study.
Heather Willmott, Caroline Gochanour, Kai Ding, Jessica Reese, Elisa Lee, Ying Zhang
Abstract read
In one paragraphArticle in Preventing chronic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
6 authors.
Heather WillmottCenter for American Indian Health Research, Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences, Oklahoma City.
Caroline GochanourCenter for American Indian Health Research, Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences, Oklahoma City.
Kai DingDepartment of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences, Oklahoma City.
Jessica ReeseCenter for American Indian Health Research, Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences, Oklahoma City.
Elisa LeeCenter for American Indian Health Research, Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences, Oklahoma City.
Ying ZhangCenter for American Indian Health Research, Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences, Oklahoma City.
Funding
The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2MSTRONG HEART STUDY (SHS): OUHSC COORDINATING CENTER - TASK AREA B (B.1 AND B.3)75N92019D00027 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, YING · 2019 to 2025
$15.5MCARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6MSTRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9MCARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9MSTRONG HEART STUDY (SHS)-MISSOURI BREAKS INDUSTRIES RESEARCH, INC.- FIELD CENTER (FC) TASK AREA B (B.1 AND B.3)75N92019D00029 · NHLBI · MISSOURI BREAKS RESEARCH, INC. · PI FRETTS, AMANDA MAE · 2019 to 2025
$7.5MSTRONG HEART STUDY (SHS)- UNIVERSITY OF OKLAHOMA-FIELD CENTER (FC), TASK AREA B.3, YEAR 375N92019D00028 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ALI, TAUQEER · 2019 to 2025
$6.5MSTRONG HEART STUDY (SHS)- MEDSTAR HEALTH RESEARCH INSTITUTE (MHRI) FIELD CENTER -SUBTASK AREA B.2 PHASE VII EXAM AND EXAM CLOSEOUT.75N92019D00030 · NHLBI · MEDSTAR HEALTH RESEARCH INSTITUTE · PI UMANS, JASON G · 2019 to 2025
$5.2MCVD in American Indians Study and Data Management Center and OK Field CenterR01HL109284 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI STONER, JULIE A · 2013 to 2018
$4.6MCARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IVU01HL065521 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2000 to 2013
$4.3MCVD in American Indians Biomarker lab and Arizona Field CenterR01HL109319 · NHLBI · MEDSTAR HEALTH RESEARCH INSTITUTE · PI UMANS, JASON G · 2013 to 2017
$3.6MCVD in American Indians Genetics CenterR01HL109301 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2013 to 2018
$3.2MNHLBI NIH HHS 75N92019D00027NHLBI NIH HHS 75N92019D00028NHLBI NIH HHS 75N92019D00029NHLBI NIH HHS 75N92019D00030NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521
6 · The paper itselfAbstract
Researchers need applicable tools to analyze and account for familial relatedness when working with family study data. In this brief article, we describe the application of 2 modeling strategies for studying the association between leukocyte telomere length and incident stroke based on data collected in the Strong Heart Family Study: the shared frailty model and the marginal Cox proportional hazards model. Although these modeling strategies are based on different theoretical frameworks, their results were similar. Future simulation study may help us to better understand the limitations and performance of each strategy in a controlled environment.
Indexed as
Models, StatisticalStrokeCluster AnalysisFemaleHumansMaleMiddle AgedProportional Hazards ModelsTelomere
Identifiers
PMID40146657
PMCPMC11974460
What OpenQuestion holds
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LicenceCC BY
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