ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025
Health-related quality of life after spontaneous subarachnoid hemorrhage - a prospective cohort study.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Quality of life after tranexamic acid in subarachnoid hemorrhage: post-hoc analysis of the ULTRA trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Trial
- Psychological and cognitive outcomes in patients with unruptured intracranial aneurysms and aneurysmal subarachnoid haemorrhage: a multidimensional assessment.Acta neurochirurgica · 2025Article
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10 authors.
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Abstract
purposeReduced health-related quality of life (HR-QoL) is common after spontaneous subarachnoid hemorrhage (SAH). Here, we aimed to describe the prevalence of HR-QoL impairment one year after SAH and to identify associated factors.
methodsIn this prospective cohort study, HR-QoL was assessed in 183 patients one year after SAH. We used the Short-Form-36 (SF-36) questionnaire, which consists of eight health domains that can be subdivided into mental and physical health components. Participants responded to scales on subjective attention deficit, mental health symptoms, and fatigue. Functional outcome was assessed with the modified Rankin Scale (mRS). Multivariable regression analysis was used to identify factors associated with reduced HR-QoL (MCS or PCS < 40).
resultsPatients were 53 years of age (IQR, 46-61) and presented with a median Hunt&Hess score of 2 (2-3). HR-QoL was reduced in 66/183 patients (36%) with the highest abnormality in physical and emotional role. A lower Hunt&Hess score (p = 0.036), female sex (p = 0.017), self-reported depression (p = 0.001), fatigue (p < 0.001), and reduction of drive (p = 0.019) were associated with overall reduced HR-QoL and explained 68.9% of the observed variance. 26% (n = 48) scored below the normal range on the MCS, and independent associations emerged for self-reported anxiety and depression, fatigue, and reduction of drive. A reduction in the PCS was reported by 35 (19%) patients and independent associations were found for worse three-month functional outcome and fatigue.
conclusionOne in three patients reported a reduction in HR-QoL one year after SAH. Mental health problems and fatigue had a significant impact on HR-QoL.
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