Evidence map›Paper›PMID 40146481›Full record

SynthesisClinical oral investigations2025

Effectiveness of root canal therapy in auto-transplanted third molars: a systematic review, meta-analysis and case series report.

Xin Yang, Lu Yin, Danyang Guo, Junzhou Chi, Shaozhen Ma, Juanxiu Liu, Yue Chen, Shunyun Luo, Kun Tian

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin YangDepartment of Stomatology, University of Electronic Science and Technology of China, Chengdu, 610050, China.
Lu YinSchool of Stomatology, Southwest Medical University, Luzhou, 646000, China.
Danyang GuoDepartment of Stomatology, University of Electronic Science and Technology of China, Chengdu, 610050, China.
Junzhou ChiSchool of Stomatology, Southwest Medical University, Luzhou, 646000, China.
Shaozhen MaDepartment of Stomatology, Sichuan Provincial People'S Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Juanxiu LiuSecond Traditional Chinese Medicine Hospital of Sichuan Province, Chengdu, 610072, China.
Yue ChenShenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, China.
Shunyun LuoOral-Dental Surgery Department, Peking Union Medical College Hospital, Beijing, 100083, China.
Kun TianDepartment of Stomatology, Sichuan Provincial People'S Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. tiankun78@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe existing literature indicates insufficient conclusive evidence regarding the efficacy of root canal therapy (RCT) in conjunction with third molar autologous tooth transplantation (ATT). This systematic review aims to evaluate the long-term survival rates and complications associated with this method. MATERIALS AND

methodsA comprehensive search was conducted across multiple databases, including PubMed, EMBASE (OVID), Web of Science (WOS), EBSCO, SpringerLink, Oxford, and ScienceDirect. This systematic review adhered to the guidelines set forth by the PRISMA and was registered in PROSPERO (CRD42024585817). This study calculated pooled survival rates, root resorption rates, and overall survival metrics. Subgroup analyses were performed to investigate the influence of follow-up duration, sample size, timing of endodontic treatment, and endodontic treatment on outcomes. Statistical significance was determined using an alpha value of 0.05, with 95% confidence intervals (CI) reported for pooled estimates. Heterogeneity was assessed using the I

resultsAmong the 17 included studies, the follow-up period ranged from 1 to 29 years. After excluding two studies with 100% survival rates, the overall 1-year survival rate was 96% (P < .0001). Studies with mixed samples showed a higher 20-year survival rate compared to those exclusively involving third molars (46.2% vs. 41.3%; P = 0.029). RCT significantly improved survival and success rates in third molar autotransplantation, though heterogeneity varies across studies. The success rate reflects the completeness of treatment and indicates the restoration of tooth function, whereas the survival rate focuses more on the long-term retention of the tooth. The higher risk difference (RD) observed in the RCT group suggests that RCT enhances both survival and success rates. This finding highlights the potential role of RCT in enhancing the success of ATT. However, significant heterogeneity was observed across studies (I

conclusionATT of third molars with intact root formation represents a reliable approach for the replacement of missing teeth, demonstrating a high survival rate. Furthermore, RCT is associated with reduced complication rates and enhanced long-term survival.

Indexed as

Molar, ThirdRoot Canal TherapyHumansTransplantation, AutologousTreatment OutcomeCase seriesMeta-analysisRoot canal therapySuccess rateSurvival rateSystematic reviewTooth auto-transplantation

Identifiers

PMID40146481
PMCPMC11950017

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.