Evidence map›Paper›PMID 40146447›Full record

ArticleClinical rheumatology2025

Lycium barbarum polysaccharide corrects CCR9

Lina Geng, Ting Li, Yan Liu, Xuntao Liu, Jing Wang, Lei Zhang, Jinliang Yang, Bin Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Bioactive spectrum of goji berries (Food chemistry: X · 2026
    Review
  2. Reversing Dysfunction of CCR9Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Article
  3. Structural-activity relationship ofFrontiers in immunology · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lina GengDepartment of Clinical Laboratory, The First Affiliated Hospital of Hebei North University, 13 Changqing Road, Zhangjiakou City, 075000, Hebei Province, China.
Ting LiDepartment of Clinical Laboratory, The First Affiliated Hospital of Hebei North University, 13 Changqing Road, Zhangjiakou City, 075000, Hebei Province, China.
Yan LiuDepartment of Clinical Laboratory, The First Affiliated Hospital of Hebei North University, 13 Changqing Road, Zhangjiakou City, 075000, Hebei Province, China.
Xuntao LiuDepartment of Clinical Laboratory, The First Affiliated Hospital of Hebei North University, 13 Changqing Road, Zhangjiakou City, 075000, Hebei Province, China.
Jing WangDepartment of Pharmacy, Zhangjiakou Second Hospital, 9 Changcheng West Street, Zhangjiakou City, 075000, Hebei Province, China.
Lei ZhangDepartment of Clinical Laboratory, The First Affiliated Hospital of Hebei North University, 13 Changqing Road, Zhangjiakou City, 075000, Hebei Province, China.
Jinliang YangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Hebei North University, 13 Changqing Road, Zhangjiakou City, 075000, Hebei Province, China.
Bin ZhangDepartment of Clinical Laboratory, The First Affiliated Hospital of Hebei North University, 13 Changqing Road, Zhangjiakou City, 075000, Hebei Province, China. 15028309589@163.com.ORCID http://orcid.org/0009-0002-3520-3249

Funding

Hebei Health Commission Scientific Research Foundation Project 20241196
6 · The paper itself

Abstract

objectivesThe imbalance of Th17 cells and Treg cells in synovium participates in rheumatoid arthritis (RA), and lycium barbarum polysaccharide (LBP) can attenuate arthritis in mice. The study aimed to explore the causes of Th17/Treg cell imbalance and investigate whether LBP could correct this imbalance in patients with RA.

methodsThe study recruited 23 healthy controls and 58 RA patients. Flow cytometry was used to analyze the percentage of C-C chemokine receptor 9

resultsIn the peripheral blood (PB) and synovial fluid (SF) of RA patients, there was a rise in the proportion of CCR9

conclusionsIn summary, the CCR9

Indexed as

Arthritis, RheumatoidDrugs, Chinese HerbalReceptors, CCRTh17 CellsT-Lymphocytes, RegulatoryAdultAgedCase-Control StudiesCell DifferentiationFemaleFlow CytometryHumansInterleukin-10Interleukin-17MaleMiddle AgedCC chemokine receptor 9Drugs, Chinese HerbalInterleukin-10Interleukin-17lycium barbarum polysaccharideReceptors, CCRCCR9+ Th17 cellsCCR9+ Treg cellsLycium barbarum polysaccharideRheumatoid arthritis

Identifiers

PMID40146447

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.