Evidence map›Paper›PMID 40146437›Full record

SynthesisNeurosurgical review2025

Olfactory changes in patients with Parkinson's disease undergoing deep brain stimulation in the subthalamic nucleus: a systematic review and meta-analysis.

Maria Antonia Oliveira Machado Pereira, Márcio Yuri Ferreira, Marcelo Porto Sousa, Izabely Dos Reis de Paula, Vitor Expedito Alves Ribeiro, Victor Gonçalves Soares, Carlos Matheus Meireles de Oliveira, Ocílio Ribeiro Gonçalves, Filipe Virgilio Ribeiro, Stefeson Gomes Cabral Junior and 5 more

Erratum issuedAbstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Maria Antonia Oliveira Machado PereiraFaculty of Medicine, State University of Piauí, Piauí, Brazil. mariaoliveirampereira@gmail.com.
Márcio Yuri FerreiraDepartment of Neurosurgery, Lenox Hill Hospital, New York, NY, USA.
Marcelo Porto SousaFaculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Izabely Dos Reis de PaulaFaculty of Medicine, State University of Piauí, Piauí, Brazil.
Vitor Expedito Alves RibeiroFaculty of Medicine, Federal University of Piauí, Piauí, Brazil.
Victor Gonçalves SoaresFaculty of Medicine, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.
Carlos Matheus Meireles de OliveiraFaculty of Medicine, State University of Piauí, Piauí, Brazil.
Ocílio Ribeiro GonçalvesFaculty of Medicine, Federal University of Piauí, Piauí, Brazil.
Filipe Virgilio RibeiroFaculty of Medicine, Barão de Mauá University Center, São Paulo, Brazil.
Stefeson Gomes Cabral JuniorFederal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Antonio Francisco Machado PereiraDepartment of Nursing, Federal University of Piaui, Piauí, Brazil.
Jacy Bezerra ParmeraMovement Disorders Center, Department of Neurology, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, Brazil.
Denise Maria Meneses Cury PortelaUniversity Center UNINOVAFAPI, Piauí, Brazil.
Herika Negri BritoDepartment of Neurosurgery, Mayo Clinic Hospital, Arizona, USA.
Gustavo Sousa NoletoUniversity of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation in the subthalamic nucleus (STN-DBS) is a therapeutic intervention for patients with Parkinson's disease (PD) primarily aimed at improving motor symptoms. However, the effects of STN-DBS on non-motor symptoms (NMS), such as olfactory dysfunction (OD), remain poorly understood. We performed a systematic review and single-arm meta-analysis to evaluate the effects of STN-DBS on OD in PD patients. We searched Medline, Scopus, and Web of Science databases. Eligible studies included observational studies with ≥ 4 patients reporting the effects of STN-DBS on OD in PD patients. Mean differences (MD) between pre- and post-operative, along with the final mean pooled analysis, olfactory scores values with 95% confidence intervals (CI) with a random effects model were used. The statistical analysis was performed using the software R Studio. The heterogeneity was assessed with I² statistics, and leave-one-out sensitivity analysis was used to address high heterogeneity. A total of seven studies, encompassing 188 PD patients, with a mean age of 60.8 years, were included in our analysis. There was a statistically significant difference between pre- and post-operative value in Odor discrimination (ODI) (MD 2.16; 95% CI 1.37 to 2.96; p < 0.01; I² = 0%) and Unified Parkinson's Disease Rating Scale part III OFF medication (UPDRS III OFF

Indexed as

Deep Brain StimulationOlfaction DisordersParkinson DiseaseSmellSubthalamic NucleusHumansTreatment OutcomeDeep brain stimulationNom-motor symptomsOlfactoryParkinson's disease

Identifiers

PMID40146437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.