ArticleEuropean radiology experimental2025
Dark-field chest radiography signal characteristics in inspiration and expiration in healthy and emphysematous subjects.
Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Assessment of emphysema with simulated low-dose dark-field radiography.European radiology experimental · 2026Article
- Feasibility of longitudinal in vivo monitoring of pulmonary disease progression in mouse models using laboratory-based x-ray dark-field CT.European radiology experimental · 2026Article
- Moiré artifact reduction in grating interferometry using multiple harmonics and total variation regularization.Scientific reports · 2026Article
- Deformable image registration of dark-field chest radiographs for functional lung assessment.Medical physics · 2025Article
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16 authors.
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Abstract
backgroundDark-field chest radiography is sensitive to the lung alveolar structure. We evaluated the change of dark-field signal between inspiration and expiration.
methodsFrom 2018 to 2020, patients who underwent chest computed tomography (CT) were prospectively enrolled, excluding those with any lung condition besides emphysema visible on CT. Participants were imaged in both inspiration and expiration with a prototype dark-field chest radiography system. We calculated the total dark-field signal ∑DF and the dark-field coefficient ϵ, assumed to be proportional to the total number of alveoli and the alveolar density, respectively.
resultsEighty-eight subjects, aged 64 years ± 11 (mean ± standard deviation), 55 males, were enrolled. Dark-field signal in the lung projection appeared higher in expiration compared to inspiration. Over all participants, ∑DF was higher in inspiration (1.6 × 10
conclusionThe dark-field signal depends on the breathing state. Differences between breathing states are influenced by emphysema severity. RELEVANCE STATEMENT: The patient's breathing state influences the dark-field chest radiograph, potentially impacting its diagnostic value. KEY POINTS: Signal characteristics in dark-field chest radiography change between inspiration and expiration. The total dark-field signal decreases slightly from inspiration to expiration, while the dark-field coefficient increases substantially. The ratio of the total dark-field signal between expiration and inspiration is independent of emphysema severity, whereas the ratio of the dark-field coefficient depends on emphysema severity.
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