Evidence map›Paper›PMID 40146373›Full record

ArticleCerebellum (London, England)2025

Anti-RGS8 Paraneoplastic Neurologic Syndrome Presenting with Skew Deviation and Mild Cerebellar Dysfunction.

Ruben Jauregui, Andrew M Evens, Anastasia Zekeridou, Claude Steriade, Todd Hudson, Gerald T Voelbel, Steven L Galetta, Janet C Rucker

Abstract readCase Reports
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In one paragraph

Article in Cerebellum (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruben JaureguiDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA. ruben.jauregui@nyulangone.org.
Andrew M EvensRutgers Cancer Institute, New Brunswick, NJ, USA.
Anastasia ZekeridouDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Claude SteriadeDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Todd HudsonDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Gerald T VoelbelDepartment of Physical Medicine and Rehabilitation, NYU Grossman School of Medicine, New York, USA.
Steven L GalettaDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Janet C RuckerDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RGS8-associated paraneoplastic neurologic syndrome (PNS) is a recently-described disorder associated with lymphomas and typically presenting with severe, rapidly-progressing cerebellar dysfunction. We describe a patient who presented with mild signs of cerebellar dysfunction, including ocular motor abnormalities and impaired tandem gait. CSF showed elevated protein and a neural-restricted antibody pattern. Mesenteric lymphadenopathy on abdominal CT was biopsied and diagnosed as follicular B-cell lymphoma. After four years, the previously-detected antibody pattern was identified as RGS8 antibodies. This case describes the first RGS8-PNS patient presenting with a subtle and ocular motor predominant cerebellar syndrome with low-grade lymphoma.

Indexed as

AutoantibodiesCerebellar DiseasesParaneoplastic Syndromes, Nervous SystemHumansAutoantibodiesCerebellar atrophyDiplopiaOcular motor abnormalitiesParaneoplastic syndromeSkew deviation

Identifiers

PMID40146373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.