Evidence map›Paper›PMID 40146372›Full record

ArticleArchives of microbiology2025

Evaluation of the antibacterial activity and mechanism of cannabigerol against drug-resistant Streptococcus iniae in vitro.

Jianing Wu, Minmin Wang, Tingke He, Xiaonan Li, Bowen Liu, Fen Chen, Yi Geng, Weiming Lai, Xiaoli Huang, Defang Chen and 1 more

Abstract read
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In one paragraph

Article in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jianing Wu *Department of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Minmin Wang *Department of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Tingke HeDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Xiaonan LiDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Bowen LiuDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Fen ChenDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Yi GengDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Weiming LaiDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Xiaoli HuangDepartment of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Defang ChenDepartment of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Ping OuyangDepartment of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. Ouyang.ping@live.cn.

Funding

This work was supported by Sichuan Innovation Team Project of Agricultural Industry Technology System SCCXTD-15
6 · The paper itself

Abstract

This study aimed to investigate the antibacterial effects and mechanism of cannabigerol against drug-resistant Streptococcus iniae. The determination of antibacterial activity was based on the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), growth curve analysis, time-kill assay, biofilm inhibition and eradication assessments. The antibacterial mechanism was explored by DNA leakage assay, assessment of cell membrane permeability, evaluation of cell membrane integrity, measurement of membrane potential, determination of respiratory chain dehydrogenase activity, and examination by using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results demonstrated that cannabigerol effectively inhibited the growth and biofilm formation of Streptococcus iniae in vitro. Mechanistically, cannabigerol induced DNA leakage, impaired cell membrane integrity, hyperpolarized membrane potential, and reduced respiratory chain dehydrogenase activity in S. iniae. In conclusion, these findings suggest that cannabigerol inhibited the growth of S. iniae by disrupting the cell membrane.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialStreptococcusBiofilmsCell MembraneCell Membrane PermeabilityMicrobial Sensitivity TestsAnti-Bacterial AgentsAntibacterial activityAntibacterial mechanismCannabigerolStreptococcus iniae

Identifiers

PMID40146372

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.