Evidence map›Paper›PMID 40146323›Full record

ReviewCalcified tissue international2025

Bone Effects of Anti-Cancer Treatments in 2024.

Marie Teissonnière, Mathieu Point, Emmanuel Biver, Peyman Hadji, Edith Bonnelye, Peter R Ebeling, David Kendler, Tobias de Villiers, Gerold Holzer, Jean-Jacques Body and 4 more

Abstract readReview
In one paragraph

Review in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Clinical guidance on evaluation and management of bone fragility in patients with monoclonal gammopathy of undetermined significance (MGUS): an IOF position statement.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  3. Bone health in patients with cancer: a SEOM-SEIOMM consensus review of risk factors, assessment strategies, and management approaches.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marie TeissonnièrePharmacie, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Mathieu PointINSERM UMR1033-LYOS, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
Emmanuel BiverDivision of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Peyman HadjiFrankfurt Center of Bone Health & Philipps University of Marburg, Frankfurt, Germany.
Edith BonnelyeUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France.
Peter R EbelingDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC, 3168, Australia.
David KendlerDepartment of Medicine (Endocrinology), University of British Columbia, Vancouver, Canada.
Tobias de VilliersDepartment Gynaecology, Stellenbosch University, Cape Town, South Africa.
Gerold HolzerMedical University of Vienna, Vienna, Austria.
Jean-Jacques BodyDepartment of Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
Ghada El Hajj FuleihanCalcium Metabolism and Osteoporosis Program WHO Center for Metabolic Bone Disorders, American University of Beirut, Beirut, Lebanon.
Maria Luisa BrandiFIRMO Foundation, Florence and University Vita-Salute San Raffaele, Milan, Italy.
René RizzoliGeneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Cyrille B ConfavreuxINSERM UMR1033-LYOS, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France. cyrille.confavreux@chu-lyon.fr.ORCID http://orcid.org/0000-0002-9318-6785

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considerable progress has been made in the management of cancer patients in the last decade with the arrival of anti-cancer immunotherapies (immune checkpoint inhibitors) and targeted therapies. As a result, a broad spectrum of cancers, not just hormone-sensitive ones, have seen several patients achieve profound and prolonged remissions, or even cures. The management of medium- and long-term side-effects of treatment and quality of life of patients are essential considerations. This is especially true for bone, as bone fragility can lead to increased fractures and loss of autonomy, ultimately reducing the possibility of resuming physical activity. Physical activity is essential for lasting oncological remission and prevention of fatigue. While the issue of hormone therapies and their association with breast cancer has been recognized for some time, the situation is relatively new with regards to targeted therapies and immunotherapies. This is particularly challenging given the wide range of available targeted therapies and their application to numerous cancer types. This article provides a comprehensive review of the bone effects of the main anti-cancer therapies currently in use. The review goes beyond glucocorticoids and hormone therapies and discusses for each drug category what is known regarding cellular effects, BMD effects, and fracture incidence.

Indexed as

Antineoplastic AgentsBone and BonesNeoplasmsBone DensityFractures, BoneHumansImmune Checkpoint InhibitorsImmunotherapyQuality of LifeAntineoplastic AgentsImmune Checkpoint InhibitorsBone mineral densitometryCancer treatment induced bone loss (CTIBL)Fracture riskOsteoblastOsteoclastSide effects

Identifiers

PMID40146323
PMCPMC11950069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.