A Prospective Study of Exosome Therapy for Androgenetic Alopecia.

backgroundAndrogenetic alopecia (AGA) is a prevalent condition that significantly impacts patients' psychological well-being and quality of life. Traditional treatments, such as minoxidil and finasteride, have limited efficacy and undesirable side effects. Exosome therapy, which uses extracellular vesicles to promote tissue regeneration, offers a promising alternative. This study evaluates the effectiveness of exosome therapy combined with microneedling (MTS) for treating AGA.

objectiveTo assess the efficacy of exosome therapy in promoting hair regrowth in patients with AGA following microneedling treatment.

methodsThis prospective, open-label study included 16 male patients aged 36-45 years with mild to moderate AGA. Microneedling was performed on the scalp followed by the application of exosome topical therapy (ZISHEL XOMAGE, Zishel Bio Inc., Seoul, Republic of Korea). Hair density and patient satisfaction were evaluated through clinical assessments and photographic documentation at 1, 3, 6, and 12 months after treatment. Side effects were also monitored.

resultsAt the 12-month follow-up, the average increase in hair density was 35 hairs/cm

conclusionExosome therapy, in combination with microneedling, offers a promising non-surgical treatment for AGA, demonstrating significant improvements in hair regrowth and patient satisfaction. Further studies with larger samples and longer follow-up periods are needed to confirm the long-term efficacy of this approach. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266 .