Evidence map›Paper›PMID 40145903›Full record

ArticleJournal of the American Chemical Society2025

An Amplificative Detection Approach for Autocatalytic Sensing of Ethylene.

Autumn I Giger, Jaiden C Voldrich, Brian W Michel

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Autumn I GigerDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, United States.
Jaiden C VoldrichDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, United States.
Brian W MichelDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, United States.ORCID 0000-0002-4737-8196

Funding

Organometallic Sensors for Cellular Small Molecule DetectionR35GM150937 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI Brian Michel · 2023 to 2026
$1.7M
NIGMS NIH HHS R35 GM150937
6 · The paper itself

Abstract

Amplified sensing offers the potential for high sensitivity; however, the vast majority of molecular strategies involve stoichiometric detection and signal transduction, including numerous recent examples of systems inspired by transition-metal-catalyzed reactions. Activation of latent precatalysts by a target analyte represents an attractive strategy for detecting low-concentration species. Analyte amplification represents another attractive approach, akin to PCR-based assays. Here we report an autocatalytic detection system based on the ethylene activation of Ru-I2 olefin metathesis precatalysts. Signal transduction is amplified by both catalytic ring closing metathesis of profluorescent substrates and ethylene propagation to activate additional units of catalyst. High sensitivity is observed as a result of this dual-mode amplified detection of ethylene. Detection of endogenous ethylene from fruit and oxidation-decomposition of polyunsaturated fatty acids via lipid peroxides is demonstrated.

Indexed as

EthylenesAlkenesCatalysisFruitOxidation-ReductionRutheniumAlkenesethyleneEthylenesRuthenium

Identifiers

PMID40145903
PMCPMC11981833

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.