Evidence map›Paper›PMID 40145873›Full record

ArticleEnvironmental science & technology2025

Trace Element Exposure during Pregnancy Has a Persistent Influence on Perinatal Gut Microbiota in Mother-Infant Dyads.

Yuqing Zhang, Xu Yang, Chao Dong, Mingzhi Zhang, Quanquan Guan, Hang Chang, Bo Hang, Jian-Hua Mao, Antoine M Snijders, Yankai Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuqing ZhangDepartment of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 210004, China.
Xu YangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, Nanjing Medical University, Nanjing 211166, China.
Chao DongState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, Nanjing Medical University, Nanjing 211166, China.
Mingzhi ZhangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, Nanjing Medical University, Nanjing 211166, China.
Quanquan GuanState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, Nanjing Medical University, Nanjing 211166, China.
Hang ChangBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Bo HangBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Jian-Hua MaoBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Antoine M SnijdersBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Yankai XiaState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, Nanjing Medical University, Nanjing 211166, China.ORCID 0000-0003-0484-4035

Funding

Role of the gut microbiome in pesticide-induced effects on child neurodevelopmentR01ES031322 · NIEHS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI MAO, JIAN-HUA · 2020 to 2024
$1.4M
NIEHS NIH HHS R01 ES031322
6 · The paper itself

Abstract

Trace elements have been recognized as the modifiers of the gut microbiota. However, population-based evidence about their effects on maternal gut microbiota dynamics, as well as the intergenerational impacts on neonatal gut microbiota, has been lacking. We examined the longitudinal microbiota data from mother-infant dyads and demonstrated that maternal trace element exposure played a pivotal role in shaping the composition and similarity of the mother-infant gut microbiota. Specifically, serum levels of cobalt (Co), molybdenum (Mo), and rubidium (Rb) were identified to cause further fluctuation in the shift of the maternal gut microbiota. Antibiotic usage shortly before or on the delivery day, as well as maternal zinc (Zn) exposure, affected the gut microbiota similarity within mother-infant dyads. Rb demonstrated an intergenerational effect on meconium

Indexed as

Gastrointestinal MicrobiomeTrace ElementsAdultFemaleHumansInfant, NewbornPregnancyTrace Elementsantibiotic usagegut microbiotamother−infant dyadstrace element

Identifiers

PMID40145873
PMCPMC13127125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.