Evidence map›Paper›PMID 40145815›Full record

ReviewAngewandte Chemie (International ed. in English)2025

Chemical Process Development in the Pharmaceutical Industry in Europe-Insights and Perspectives from Industry Scientists.

Joachim Krueger, André P Dieskau, Jorma Hassfeld, Joerg Gries, Oliver Block, Hilmar Weinmann, Daniel Kaufmann, Stefan Hildbrand, Volker Kraft, Robert Moeckel and 3 more

Abstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Phage Display as a Promising Platform for Peptide Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. An Update: Enzymatic Synthesis for Industrial Applications.Angewandte Chemie (International ed. in English) · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joachim KruegerPharmaceuticals CMC & Technology, Bayer AG, D-42096, Wuppertal, Germany.
André P DieskauPharmaceuticals CMC & Technology, Bayer AG, D-42096, Wuppertal, Germany.
Jorma HassfeldPharmaceuticals CMC & Technology, Bayer AG, D-42096, Wuppertal, Germany.
Joerg GriesPharmaceuticals CMC & Technology, Bayer AG, D-42096, Wuppertal, Germany.
Oliver BlockGlobal CMC Development, Merck Healthcare KGaA, D-64293, Darmstadt, Germany.
Hilmar WeinmannChemical Process R&D, Johnson & Johnson Innovative Medicine, Beerse, B-2340, Belgium.
Daniel KaufmannChemical & Analytical Development, Novartis AG, Basel, CH-4056, Switzerland.
Stefan HildbrandProcess Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, CH-4070, Switzerland.
Volker KraftR&D Global CMC Development Synthetics, Sanofi-Aventis Deutschland GmbH, D-65926, Frankfurt, Germany.
Robert MoeckelChemical Development, Boehringer Ingelheim Pharma GmbH & Co. KG, D-55216, Ingelheim am Rhein, Germany.
Juan R DehliChemical Development, Boehringer Ingelheim Pharma GmbH & Co. KG, D-55216, Ingelheim am Rhein, Germany.
Ulrich ScholzChemical Development, Boehringer Ingelheim Pharma GmbH & Co. KG, D-55216, Ingelheim am Rhein, Germany.
Carl Friedrich NisingPharmaceuticals CMC & Technology, Bayer AG, D-42096, Wuppertal, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical process development is a critical component in the development process for active pharmaceutical ingredients (APIs). With interfaces to drug discovery and API manufacturing, chemical process development activities must deliver scalable, safe, cost-efficient, sustainable, and reliable processes for novel as well as marketed APIs. Despite its importance for the pharmaceutical industry and society, the domain of chemical process development, together with its advances and challenges, is often not well known to nonpractitioners. As industry scientists, we provide a scientific perspective on the state of affairs in chemical process development, which we believe will be of value to a broader audience, including academic researchers, students, and professionals from related fields.

Indexed as

Drug IndustryDrug DiscoveryEuropePharmaceutical PreparationsPharmaceutical PreparationsDrug developmentDrug discoveryIndustrial chemistryPharmaceutical industryProcess chemistry

Identifiers

PMID40145815
PMCPMC12051753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.