ArticleACS nano2025
High-Precision Biochemical Sensing with Resonant Monocrystalline Plasmonic Ag Microcubes in the Mid-Infrared Spectrum.
Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Dynamically tunable membrane metasurfaces for infrared spectroscopy and strong light-matter interactions.Light, science & applications · 2026Article
- Unlocking the Translational Potential of Nanophotonic Biosensors: Perspectives on Application-Guided Design.ACS photonics · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
Infrared (IR) spectroscopic fingerprinting is a powerful analytical tool for characterizing molecular compositions across biological, environmental, and industrial samples through their specific vibrational modes. Specifically, when the sample is characterized in resonant plasmonic cavities, as in the surface-enhanced mid-IR absorption spectroscopy (SEIRAS), highly sensitive and specific molecular detection can be achieved. However, current SEIRAS techniques rely on nanofabricated subwavelength antennas, limited by low-throughput lithographic processes, lacking scalability to address broad biochemical sensing applications. To address this, we present an on-resonance SEIRAS method utilizing silver (Ag) cubic microparticles (Ag-CMPs) with robust mid-IR plasmonic resonances. These monocrystalline Ag-CMPs, featuring sharp edges and vertices, are synthesized via a high-throughput, wet-chemical process. When dispersed on gold mirror substrates with an aluminum oxide spacer, Ag-CMPs support enhanced near-field light-matter interactions in nanocavities while enabling far-field imaging-based optical interrogation due to their strong extinction cross sections. We demonstrate the detection of polydimethylsiloxane (PDMS) and bovine serum albumin (BSA) monolayers by simply probing individual Ag-CMPs, enabled by the resonant amplification of the characteristic vibrational absorptions. Furthermore, our single-particle SEIRAS (SP-SEIRAS) approach effectively analyzes complex human peritoneal fluid (PF) samples, eliminating the challenges of standard bulk sample measurements. This scalable and efficient SP-SEIRAS method addresses key limitations of IR spectroscopic fingerprinting techniques, unlocking possibilities for their widespread adoption in real-world biochemical sensing applications.
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Registered trials
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