ArticleApplied and environmental microbiology2025
The GCN4-Swi6B module mediates low nitrogen-induced cell wall remodeling in
Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Combined Transcriptomic and Metabolomic Analyses of the Response ofJournal of fungi (Basel, Switzerland) · 2025Article
- Transcriptome and gene co-expression network analysis revealed a putative regulatory mechanism of low nitrogen response in rice seedlings.Frontiers in plant science · 2025Article
- Analysis of the chitin synthase gene family inPeerJ · 2025Article
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Authors and funding
8 authors.
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Abstract
In natural habitats, microorganisms encounter various unfavorable environmental stresses, including nitrogen deficiency. As the outermost barrier, the cell wall plays a crucial role in the interaction between the cell and the external environment. However, the effect of low nitrogen on cell wall thickness, especially the underlying molecular mechanism, is unclear. Here, we found that compared with those under normal nitrogen conditions, both the cell wall thickness and polysaccharide content of IMPORTANCE: To survive in stressful environments, fungi initiate cell wall remodeling pathways to adaptively modify the cell wall composition and structure. Here, we found that nitrogen deficiency upregulated the cell wall polysaccharide content and cell wall thickness through the GCN4-SWI6B signaling pathway. Our findings provide valuable insights into the environmental adaptation of fungal cell walls, contributing to a deeper understanding of fungal responses to environmental stress.
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