Trial reportCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2025
Left Ventricular Unloading in Nonischemic Dilated Cardiomyopathy Improves Coronary Haemodynamic Reserve.
Trial report in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03572660 (Phase II Study Assessing the Combined Use of Autologous Bone Marrow Derived Mononuclear Cells and G-csf With Percutaneous Circulatory Assistance in the Treatment of Dilated Cardiomyopathy), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase II Study Assessing the Combined Use of Autologous Bone Marrow Derived Mononuclear Cells and G-csf With Percutaneous Circulatory Assistance in the Treatment of Dilated Cardiomyopathy
Who cites it
2 citing papers in PubMed.
- Procedural circulatory support-enabled intracoronary cell delivery in advanced dilated cardiomyopathy.iScience · 2026Article
- Coronary Microvascular Dysfunction in Cardiomyopathies: Insights on Clinical and Prognostic Roles.Reviews in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundThe Impella CP is a catheter-based ventricular assist device used in the management of cardiogenic shock and to support high-risk percutaneous coronary interventions (PCI). Despite its growing use, the effects of Impella CP on coronary flow dynamics as measured by intracoronary continuous thermodilution have not been fully quantified.
aimsThis study aimed to evaluate the impact of percutaneous ventricular unloading (PVU) with Impella CP on coronary flow reserve (CFR) and microvascular resistance reserve (MRR) in patients with severe nonischemic dilated cardiomyopathy undergoing intracoronary infusion of autologous bone-marrow derived mononuclear cells (BMMNCs).
methodsCoronary flow (Q) was assessed using intracoronary continuous thermodilution both at rest (Qrest) and during hyperemia (Qhyper) before and after PVU with the Impella CP. Measurements were performed in the left anterior descending (LAD) artery using a dedicated pressure/thermistor coronary guidewire. CFR and MRR were calculated post-hoc.
resultsNine patients underwent investigation with continuous thermodilution. Initiation of LV unloading with Impella CP resulted in a significant increase in CFR (from 2.72 ± 0.76, to 3.9 ± 1.84, p = 0.049) and MRR (from 3.09 ± 0.97, to 4.50 ± 1.93 p = 0.022). A decrease in mean Qrest and an increase in mean Qhyper was also noted.
conclusionsPVU with Impella CP led to a significant increase CFR and MRR, suggesting an improvement in coronary haemodynamic reserve. Further studies are needed to validate these findings in a larger patient population.
trial registrationClinicaltrials. org: DCM Support NCT03572660.
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