ArticleNeurogastroenterology and motility2025
Acute Cervical Vagus Nerve Stimulation Modulates Gastric Slow Waves in the Distal Rat Stomach.
Article in Neurogastroenterology and motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Electroacupuncture and vagus nerve stimulation are emerging therapies for hyperemesis gravidarum management.Frontiers in neurology · 2025Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundGastric motility is coordinated by bioelectrical events, named slow waves, which propagate across the stomach. Gastric dysrhythmias are associated with disorders of gut-brain interaction. Electrical cervical vagus nerve stimulation (cVNS) affects gastric contractions, but associated changes in gastric slow waves have not been quantified.
methodsThree cVNS protocols (low: 0.30 ms, 0.25 mA, 1 Hz; medium: 0.50 ms, 0.50 mA, 5 Hz; high: 1.00 ms, 1.00 mA, 10 Hz) were administered to six rats. Gastric slow waves were concurrently recorded from the serosa of the antrum and distal corpus using flexible electrode arrays. Slow wave amplitude and frequency (mean ± standard deviation) were analyzed with a mixed linear effects model. KEY
resultscVNS had no effect on mean slow wave amplitude (p ≥ 0.2208). Slow wave frequency decreased during the high stimulation protocol compared to sham (3.93 ± 0.90 cpm to 3.49 ± 0.54 cpm, p = 0.0374, antrum; 3.94 ± 1.04 cpm to 3.15 ± 0.53 cpm, p < 0.0001, distal corpus) but returned to sham levels after a recovery period (p = 0.9190, antrum; p = 0.9995, distal corpus). Ectopic activation of gastric slow waves occurred during cVNS, resulting in a transient effect on gastric slow wave frequency and propagation but not amplitude. CONCLUSIONS & INFERENCES: Slow wave activity was modified by acute medium and high cVNS stimulation protocols with changes in propagation patterns and mean frequency. Therefore, modified slow wave activity could affect gastric motility function during acute cVNS.
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