ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Racial and ethnic differences in white matter hypointensities: The role of vascular risk factors.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Depressive symptoms and neuroimaging markers of brain aging in an ethno-racially diverse sample: a Bayesian analysis.American journal of epidemiology · 2026Article
- Heterogeneity in the association between cardiovascular disease and cognitive decline: a pooled analysis of five prospective cohort studies from 24 countries.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Education, Cognitive Reserve, and Brain Pathology in Aging and Alzheimer's Disease: Evidence from Preclinical and Symptomatic Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Do white matter hyperintensities account for the relationship between discrimination and memory?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Vascular risk factors mediate the relationship between education and white matter hyperintensities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Quantifying brain atrophy in Frontotemporal Dementia: a head-to-head comparison of neuroimaging techniques.medRxiv : the preprint server for health sciences · 2025Article
- Racial and ethnic differences in cardiometabolic predictors of white matter hyperintensities burden among males: The HABS-HD study.Journal of Alzheimer's disease : JAD · 2025Article
- Dissecting real-world memory clinical cohort heterogeneity: analysis of neuroanatomical subtypes using HYDRA.Alzheimer's research & therapy · 2025Article
- Distinct Longitudinal Clinical-Neuroanatomical Trajectories in Parkinson's Disease Clinical Subtypes: Insight toward Precision Medicine.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Racial and ethnic differences in white matter hypointensities: The role of vascular risk factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Intersecting vulnerabilities: race, depression, and white matter hypointensity burden in aging.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Intracranial volume: To adjust or not to adjust? It is not a matter of if, but how.Imaging neuroscience (Cambridge, Mass.)Article
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4 authors.
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Abstract
introductionWhite matter hypointensities (WMHs) are markers of cerebrovascular pathology associated with cognitive decline. Reports of racial and ethnic differences in WMHs have been inconsistent across studies. This study examined whether race and ethnicity influence WMH burden and whether vascular risk factors explain these differences.
methodsData from the National Alzheimer's Coordinating Center included 7132 Whites, 892 Blacks, 283 Asians, and 661 Hispanics. Baseline and longitudinal WMHs were examined using linear regression and mixed-effects models across racial and ethnic groups, controlling for demographics and vascular risk factors.
resultsAdjusting for vascular risk factors reduced WMH burden differences and eliminated differences in temporal regions in Black versus White older adults. For Hispanics, differences became significant after adjusting for vascular risk factors. DISCUSSION: Although some racial and ethnic WMH disparities are influenced by vascular risk factors, others persist, highlighting the need for multidimensional approaches when targeting WMHs in diverse populations. HIGHLIGHTS: Current research is inconsistent as to whether there are racial differences in white matter hypointensities (WMHs). Blacks exhibit higher WMH burden than Whites, mediated by vascular factors. In Hispanics, WMH differences emerged only after adjusting for vascular risk factors.
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