ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Brain structural alterations in young women with premature ovarian insufficiency: Implications for dementia risk.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Premature and early menopause and neuroimaging biomarkers of neurodegenerative diseases: a systematic review.Frontiers in dementia · 2026Pooled it
- Dietary phytoestrogen ameliorates ovarian toxicant-induced neurotoxicity: mechanistic and metabolic insights.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Gonadotropins Across the Lifespan: Their role in the Neurodevelopment-Neurodegeneration Continuum.The Yale journal of biology and medicine · 2026Review
- Epigenetic dysregulation of steroidogenesis and neuroactive steroid deficiency in premature ovarian insufficiency: implications for neurodegenerative risk.Biomarker research · 2025Article
- An Evidence-Based Approach to the Management of Primary Ovarian Insufficiency in Adolescents and Young Women.Life (Basel, Switzerland) · 2025Article
- Brain structural alterations in young women with premature ovarian insufficiency: Implications for dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Voxel- and surface-based morphometry in the cortical thickness and cortical and subcortical gray matter volume in patients with mild-to-moderate Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
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14 authors.
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Abstract
introductionPremature ovarian insufficiency (POI), marked by ovarian function loss before age 40, is linked to a higher risk of dementia, including Alzheimer's disease (AD). However, the associated brain structural changes remain poorly understood.
methodsWe analyzed T1-weighted and diffusion tensor imaging in 33 idiopathic POI women and 51 healthy controls, using voxel-based, surface-based morphometry, and network analyses to assess gray matter volume (GMV), cortical thickness, and brain connectivity.
resultsWomen with POI showed significant GMV and cortical thickness reductions in the frontal, parietal, and temporal regions (p < 0.05), alongside impaired connectivity with key regions such as the hippocampus, thalamus, and amygdala (p < 0.05). Younger POI subgroups exhibited changes in more widespread brain regions. In additionally, notable atrophy was observed in specific hippocampal and thalamic subregions in POI (p < 0.05). DISCUSSION: This preliminary study suggests early neurodegenerative patterns in POI, potentially contributing to dementia risk. Further research is needed to explore the underlying mechanisms and potential interventions. HIGHLIGHTS: We evaluated brain structural changes in participants with idiopathic premature ovarian insufficiency (POI). The observed brain alterations in POI participants closely resemble those seen in early dementia, including regions specifically associated with Alzheimer's disease (AD). These findings highlight the critical need for early interventions to reduce the long-term risks of cognitive impairment and dementia in women with POI.
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