Evidence map›Paper›PMID 40145291›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Driving research on successful aging and neuroprotection in Latin America: Insights from the inaugural symposium on brain resilience and healthy longevity.

Yakeel T Quiroz, David Aguillón, Joseph Arboleda-Velasquez, Yamile Bocanegra, Gloria Patricia Cardona-Gómez, Maria M Corrada, Ibai Diez, Elkin Garcia-Cifuentes, Kenneth Kosik, Lusiana Martinez and 9 more

Abstract readReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yakeel T QuirozHarvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.
David AguillónGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Calle 62 # 52 -59, Sede de Investigación Universitaria - SIU, Medellín, Colombia.
Joseph Arboleda-VelasquezSchepens Eye Research Institute, Mass Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
Yamile BocanegraGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Calle 62 # 52 -59, Sede de Investigación Universitaria - SIU, Medellín, Colombia.
Gloria Patricia Cardona-GómezGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Calle 62 # 52 -59, Sede de Investigación Universitaria - SIU, Medellín, Colombia.
Maria M CorradaDepartment of Neurology and Department of Epidemiology & Biostatistics, University of California, Irvine, California, USA.
Ibai DiezHarvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.
Elkin Garcia-CifuentesGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Calle 62 # 52 -59, Sede de Investigación Universitaria - SIU, Medellín, Colombia.
Kenneth KosikUniversity of California, Santa Barbara, California, USA.
Lusiana MartinezHarvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.
David Pineda-SalazarGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Calle 62 # 52 -59, Sede de Investigación Universitaria - SIU, Medellín, Colombia.
Rafael PosadaGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Calle 62 # 52 -59, Sede de Investigación Universitaria - SIU, Medellín, Colombia.
Norbel RomanGrupo de Trabajo de Trastornos del Movimiento de Centro América, MDS, San Pedro Montes de Oca, Universidad de Costa Rica, CIHATA, San José, Costa Rica.
Diego Sepulveda-FallaInstitute of Neuropathology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
Andrea SlachevskyGerosciences Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Marcio Soto-AñariUniversidad Católica San Pablo, Urb. Campiña Paisajista, s/n, Quinta Vivanco, Arequipa, Peru.
Evelyn TabiloGerosciences Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Daniel VasquezGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Calle 62 # 52 -59, Sede de Investigación Universitaria - SIU, Medellín, Colombia.
Andrés Villegas-LanauGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Calle 62 # 52 -59, Sede de Investigación Universitaria - SIU, Medellín, Colombia.

Funding

Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older LatinosR01AG066823 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2021 to 2025
$4.2M
Resilience to Cognitive Decline and Resistance to Alzheimer's Disease and Related Neurodegenerative Diseases in Individuals from Colombia with Autosomal Dominant DementiasRM1NS132996 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AGUILLON, DAVID FERNANDO, ARBOLEDA-VELASQUEZ, JOSEPH · 2023 to 2023
$3.8M
Nerve growth factor (NGF) metabolic dysfunction as a marker of cognitive decline in autosomal dominant Alzheimer's diseaseRF1AG077627 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI AGUILLON, DAVID FERNANDO, CUELLO, A CLAUDIO · 2022 to 2022
$2.0M
Good VenturesNational Institute of Neurological Disorders and Stroke (NINDS) RM1NS132996NIA NIH HHS R01 AG066823NIA NIH HHS R01AG066823NIA NIH HHS RF1 AG077627NIA NIH HHS RF1AG077627NINDS NIH HHS RM1 NS132996
6 · The paper itself

Abstract

introductionGlobal life expectancy has steadily increased in recent decades, resulting in a significant rise in the number of individuals aged 80 years and older. This trend is also evident in Latin America, where life expectancy is improving, though at varying rates across countries and regions.

methodsPartnering with the Neurosciences Group of Antioquia (GNA), we launched a Colombian study on resilience in families with autosomal dominant Alzheimer's disease and the oldest-old population. Over the past 2 years, the project has expanded to include participants from Peru, Chile, and Costa Rica.

resultsThis research led to the first symposium on Brain Resilience and Healthy Longevity, held in Medellín, Colombia, in August 2024. DISCUSSION: The article summarizes key discussions from the symposium, highlighting the most promising opportunities for brain resilience and prevention research in the region and offering recommendations for future research to promote healthy aging and dementia-free communities. HIGHLIGHTS: Uncovering the genetic and physiological drivers of cognitive resilience, neurodegeneration resistance, and healthy longevity is essential for maintaining brain function as we age. "Superagers" and cognitively resilient individuals from Latin American families with Alzheimer's disease offer valuable insights into brain protection mechanisms. Studying the interplay of socio-environmental and genetic factors in the oldest-old is key to understanding healthy longevity and improving dementia prevention. The inaugural Brain Resilience and Healthy Longevity Symposium highlights the need for global collaboration to uncover factors that drive cognitive resilience and healthy aging in Latin America, advancing dementia prevention.

Indexed as

AgingBrainHealthy AgingLongevityNeuroprotectionAged, 80 and overAlzheimer DiseaseCongresses as TopicHumansLatin AmericaLife ExpectancyAlzheimer's resistancebrain resiliencehealthy agingLatin Americaoldest‐old

Identifiers

PMID40145291
PMCPMC11947765

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.