SynthesisJournal of cosmetic dermatology2025
Treatment of Solar Lentigines: A Systematic Review of Clinical Trials.
Synthesis in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Instrumental Assessment of a Chemical Skin Biostimulator Combining Ammonium Trichloroacetate and Homocysteic Acid in Photoaged Mature Skin: A Single-Arm Prospective Study.Molecules (Basel, Switzerland) · 2026Article
- Kojic Acid as a Natural Hypopigmenting Agent: Biological Activities, Delivery Challenges, and Nanotechnology-Based Strategies.Pharmaceutics · 2026Review
- Safety and Efficacy of Laser Versus Cryotherapy in the Treatment of Lentigines: A Systematic Review and Meta-analysis of Randomized Controlled Trials : Short title: Safety and Efficacy of Laser Versus Cryotherapy in the Treatment of Lentigines.Galen medical journal · 2026Article
- Targeting Melanogenesis with Postbiotics: An Integrated Zebrafish-Based Assessment ofMolecules (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSolar lentigines, resulting from chronic UV exposure, are early signs of photoaging and can significantly affect individuals.
aimsThis systematic review evaluates the efficacy, safety, and tolerability of treatments for solar lentigines in light of a lack of conclusive evidence regarding optimal therapy options.
methodsA systematic search of PubMed/Medline, EMBASE, Cochrane Library, and clinicaltrials.gov was conducted to identify relevant clinical trials published up to December 7, 2023. Inclusion criteria encompassed studies with patients diagnosed with solar lentigines, employing clinical trial methodologies and reporting clinical outcomes. Study quality was assessed using the Cochrane tool.
resultsForty-one clinical trials involving 3234 patients aged 24-92 years were included. The most common effective topical treatment was a combination of mequinol 2% and tretinoin 0.01%, achieving efficacy rates between 52.6% and over 80%, particularly for facial lesions. Laser therapies demonstrated promising results: pulsed dye laser (27%-57% success), intense pulsed light (74.6%-90%), Q-Switched laser (36.36%-76.6%), picosecond laser (67.9%-93.02%), and fractional CO
conclusionsLaser therapy appears more effective than other modalities, with an acceptable safety profile. Combining lasers with specific topical agents may further improve outcomes and reduce PIH. However, additional large-scale randomized trials are required to confirm these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.