Evidence map›Paper›PMID 40145242›Full record

ArticleJournal of cosmetic dermatology2025

The Impact of Acoustic Wave Therapy on Viability and Differentiation Capacity of Human Adipose Stem Cells.

Sheila Veronese, Riccardo Ossanna, Sara Ghazanfar Tehrani, Paolo Bernardi, Sima Khabouri, Velia Cannone, Maria Maddalena Nicoletti, Mario Goisis, Andrea Sbarbati

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sheila VeroneseDepartment of Neuroscience, Biomedicine, and Movement, Section of Anatomy and Histology, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-6707-3306
Riccardo OssannaDepartment of Neuroscience, Biomedicine, and Movement, Section of Anatomy and Histology, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0003-4890-129X
Sara Ghazanfar TehraniDepartment of Neuroscience, Biomedicine, and Movement, Section of Anatomy and Histology, University of Verona, Verona, Italy.
Paolo BernardiDepartment of Neuroscience, Biomedicine, and Movement, Section of Anatomy and Histology, University of Verona, Verona, Italy.
Sima KhabouriDe Clinic, Milan, Italy.
Velia CannoneDepartment of Neuroscience, Biomedicine, and Movement, Section of Anatomy and Histology, University of Verona, Verona, Italy.
Maria Maddalena NicolettiDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Mario GoisisDe Clinic, Milan, Italy.
Andrea SbarbatiDepartment of Neuroscience, Biomedicine, and Movement, Section of Anatomy and Histology, University of Verona, Verona, Italy.

Funding

Storz Medical AG
6 · The paper itself

Abstract

backgroundAcoustic Wave Therapy (AWT) is a particular shock wave treatment that combines focused and radial shock waves, resulting in particular efficiency in the body's superficial layers. Its application before fat grafting has the potential to enhance it, favoring a better result of the graft.

aimsThe aim of this study was to analyze the effects of AWT on fat tissue.

methodsHistological analysis of fat harvested from the abdomen of 40 subjects was evaluated. Twenty subjects had been pre-treated with AWT, while 20 had not. Extraction and characterization of adipose-derived stem cells (ADSCs) were performed for all. The multilineage differentiation capacity of extracted ADSCs and exosome extracellular vesicles' production from the fat samples were analyzed in both groups of specimens.

resultsAll 40 specimens presented both preservation of the structure of the tissue and of the cells, particularly of adipocytes. The cell growth resulted higher for pre-treated samples. All ADSCs from all the samples were able to differentiate along adipogenic, chondrogenic, and osteogenic lineages. In particular, for pre-treated samples, in the adipogenic lineage, a more advanced maturation phase was observed, and in the chondrogenic lineage, a chondroid matrix was evident around chondrocyte aggregates. All the samples reacted with exosome extracellular vesicles' production to stress.

conclusionsThe results highlighted that AWT aligns with the in-force minimal manipulation regulations, as the tissue and cells' structure and functionality were preserved. The types of differentiation observed permitted us to speculate about possible new applications in aesthetic and regenerative medicine.

Indexed as

AdipocytesAdipose TissueStem CellsAdipogenesisAdultCell DifferentiationCells, CulturedCell SurvivalChondrogenesisExosomesFemaleHumansMaleMiddle AgedOsteogenesisadipose tissueADSCsdifferentiationextracellular vesiclesfat graftingshock waves

Identifiers

PMID40145242
PMCPMC11948166

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.