Evidence map›Paper›PMID 40145241›Full record

ArticleMuscle & nerve2025

Sensory Nerve Conduction Amplitudes and Z-Compounds Depend on Body Mass Index in Overweight and Obese Individuals.

Trond Sand, Martin Uglem, Gjermund Johnsen, Arnstein Grøtting, Øystein Dunker, Jorunn Sandvik, Kristian B Nilsen

Abstract read
In one paragraph

Article in Muscle & nerve, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Trond SandDepartment of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.ORCID https://orcid.org/0000-0002-9755-8187
Martin UglemDepartment of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Gjermund JohnsenDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Arnstein GrøttingDepartment of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Øystein DunkerDepartment of Research and Innovation, Division of Neuroscience, Oslo University Hospital, Oslo, Norway.ORCID https://orcid.org/0000-0003-1280-7656
Jorunn SandvikDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Kristian B NilsenSection for Clinical Neurophysiology, Department of Neurology, Oslo University Hospital, Oslo, Norway.

Funding

Liaison Committee for Education, Research and Innovation in Central Norway
6 · The paper itself

Abstract

INTRODUCTION/

aimsThe association between body mass index (BMI) and nerve conduction study (NCS) amplitudes has not been adequately studied in overweight and obese subjects. Our aim was to estimate the impact of high BMI on NCS amplitudes and NCS summary measures.

methodsOne hundred and seventy-five patients with previous gastric bypass surgery and 86 subjects from the general population had clinical evaluations and NCS of upper and lower limbs. Subjects with diabetes, mononeuropathy, or polyneuropathy (PNP) were excluded. Eighty-three former patients with a mean age of 48 years (SD 8), BMI mean = 34.3 kg/m

resultsMost sensory amplitudes and tibial nerve motor amplitude decreased significantly with increasing BMI. The magnitudes of association were comparable for BMI and age. A new Z-compound for sensory amplitudes correlated moderately strongly with BMI for subjects with BMI < 30 kg/m DISCUSSION: Sensory NCS amplitudes depend on BMI in obese and non-obese subjects. Lower reference limits for several sensory amplitudes should probably be adjusted for BMI. Reference limits for amplitude-dependent Z-compounds should be corrected for BMI. The findings have relevance for all patients investigated with nerve conduction studies, in particular, patients with suspected axonal polyneuropathies.

Indexed as

Body Mass IndexNeural ConductionObesityOverweightAdultAgedFemaleHumansMaleMiddle AgedYoung Adultnerve conduction study (NCS)neurographyobesity (BMI)overweightsensory nerve action potential (SNAP)

Identifiers

PMID40145241
PMCPMC12060630

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.