ArticleJHLT open2024
Afterload pressure and left ventricular contractility synergistically affect left atrial pressure during veno-arterial ECMO.
Article in JHLT open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Comparison of Left Ventricular Pressure-Volume Loops With Veno-Arterial Extracorporeal Membrane Oxygenator Support: In Vitro Investigation.Artificial organs · 2026Article
- Learning from a pitfall: Atrial septostomy in LV failure under VA-ECMO for pulmonary hypertension.The journal of extra-corporeal technology · 2026Article
- Hemi-ECMO: A Novel Method of Left Ventricular Afterload Reduction for Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO).Bioengineering (Basel, Switzerland) · 2026Article
- VV-ECMO Combined With M-TEER for the Treatment of Mitral Valve Papillary Muscle Rupture Following Acute Myocardial Infarction PCI: A Case Report.Clinical case reports · 2026Article
- A Canadian Experience With a Percutaneous Microaxial Ventricular Assist Device in Children With Cardiogenic Shock.CJC pediatric and congenital heart disease · 2025Article
- Increased VA-ECMO Pump Speed Reduces Left Atrial Pressure: Insights from a Novel Biventricular Heart Model.Bioengineering (Basel, Switzerland) · 2025Article
- Lung injury in myocardial infarction-associated cardiogenic shock supported by venoarterial extracorporeal membrane oxygenation: a scoping review.BMC cardiovascular disorders · 2025Article
- Impact of aortic morphology on VA-ECMO performance: a combined statistical shape modeling and CFD approach.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Veno-arterial extra-corporeal membrane oxygenation (VA-ECMO) may cause adverse effects including increased left ventricular (LV) filling pressure, LV distension, and pulmonary edema. We aimed to quantify the effects of ECMO flow, LV contractility, aortic pressure (AoP), and ECMO configuration on left atrial pressure (LAP) during VA-ECMO for cardiogenic shock in a mock circulatory loop (MCL). Methods: An MCL simulated a normal state, LV failure, right ventricular failure, and biventricular failure. The ECMO return cannula was placed in the femoral artery (retrograde flow) or ascending aorta (antegrade flow). ECMO flow was incrementally increased from 0 to 5 liter/min. LAP, mean AoP, ECMO flow, and total cardiac output were measured at steady state. Results: During VA-ECMO, LAP increased linearly with AoP, with the slope greater in the presence of LV impairment compared to preserved LV function. When AoP was held constant, as is the goal of therapy in clinical management, ECMO flow had no effect on LAP. In multivariable linear regression, AoP and LV contractility ( Conclusions: AoP and LV contractility, but not circuit flow or direction, independently determine LAP under VA-ECMO support. By controlling each of these inputs, vasodilator and inotrope management may combine synergistically to prevent VA-ECMO-related complications.
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Registered trials
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