Evidence map›Paper›PMID 40145058›Full record

ArticleJHLT open2024

Higher soluble thrombomodulin and angiogenic markers in continuous flow left ventricular assist device-supported patients associated with arteriovenous malformation and nonsurgical bleeding.

Kavitha Muthiah, Louise L Dunn, Hunter Eckford, David Connor, Desiree Robson, Peter S Macdonald, Christopher S Hayward

Abstract read
In one paragraph

Article in JHLT open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kavitha MuthiahHeart Failure and Transplant Unit, St. Vincent's Hospital, Sydney, Australia.
Louise L DunnVictor Chang Cardiac Research Institute, Sydney, Australia.
Hunter EckfordHeart Failure and Transplant Unit, St. Vincent's Hospital, Sydney, Australia.
David ConnorSt. Vincent's Centre For Applied Medical Research, Sydney, Australia.
Desiree RobsonHeart Failure and Transplant Unit, St. Vincent's Hospital, Sydney, Australia.
Peter S MacdonaldHeart Failure and Transplant Unit, St. Vincent's Hospital, Sydney, Australia.
Christopher S HaywardHeart Failure and Transplant Unit, St. Vincent's Hospital, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bleeding complications are a bane of continuous flow left ventricular assist devices (cfLVAD); gastrointestinal bleeding (GIB) from arteriovenous malformation (AVM) predominating. We hypothesized that shear stress disrupts vascular endothelium altering angiogenesis and contributing to bleeding. We profiled markers of endothelial dysfunction (soluble thrombomodulin [sTM]) and angiogenesis (angiopoietin-1 [Ang-1], angiopoietin-2 [Ang-2]) in 21 patients implanted with a centrifugal cfLVAD. Bleeding episodes were documented in 11 patients, 8 had GIB, 4 of whom had AVMs. We observed a dynamic change in sTM and Ang-2/Ang-1 ratio following cfLVAD support (

Indexed as

angiogenesisarteriovenous malformationgastrointestinal bleedingleft ventricular assist devicemechanical circulatory support

Identifiers

PMID40145058
PMCPMC11935490

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.