Evidence map›Paper›PMID 40144999›Full record

ArticleFrontiers in public health2025

Association of ethylene oxide exposure with serum neurofilament light chain levels among American adults.

Xiuwen Yang, Huaili Feng, Ting You, Zhaoyi Liu, Fanwei Sun, Chengzhi Chen, Jingfu Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiuwen Yang *Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, China.
Huaili Feng *Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, China.
Ting YouResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, China.
Zhaoyi LiuResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, China.
Fanwei SunFaculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Chengzhi ChenResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, China.
Jingfu QiuResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the relationship between Ethylene oxide (EO) expousure and serum neurofilament light chain (NfL). Method: A data of 559 adults from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) was analyzed, and the relationship between log-transformed EO hemoglobin adducts (HbEO) and serum NfL levels was assessed using multiple linear regression models and restricted cubic spline functions. Stratified analysis was conducted to explore the correlations within different subgroups. Mediation analysis was employed to investigate potential mediating factors. Results: The higher HbEO levels were consistently associated with elevated serum NfL concentrations among the study participants ( Conclusion: These findings highlighted the neurotoxic potential of EO and underscored the importance of monitoring EO exposure to mitigate its adverse health effects.

Indexed as

Environmental ExposureEthylene OxideNeurofilament ProteinsAdultAgedBiomarkersFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesBiomarkersEthylene Oxideneurofilament protein LNeurofilament Proteinsadultsethylene oxideneurofilament light chainneurotoxicityNHANES

Identifiers

PMID40144999
PMCPMC11938061

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.