ArticleOsteoarthritis and cartilage open2025
Immobilization by 21-days of bed rest causes changes in biomarkers of cartilage homeostasis in healthy individuals.
Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Motion as Medicine: Physical Activity, Joint Sensitivity, and Pain Management-A Narrative Review.Medical sciences (Basel, Switzerland) · 2026Review
- Microgravity-induced transcriptional reprogramming in embryonic chicken limb bud-derived chondrogenic cultures.Frontiers in cell and developmental biology · 2026Article
- A Multidimensional Definition of Pre-Osteoarthritis: Toward 21st-Century Subclinical Detection and Targeted Intervention.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the effects of 21 days bed rest immobilization (with and without exercise and nutrition intervention) on serum concentrations of cartilage homeostasis biomarkers in healthy individuals. Design: Twelve male volunteers (age 34.2 ± 8.3 years; BMI 22.4 ± 1.7 kg/m Results: The main effect of time was significant for all biomarkers tested (p < 0.001). While COMP (-36 % at HDT5, p < 0.001) and MMP-3 (-36 % at HDT21, p < 0.001) decreased during HDT bed rest, MMP-9 (+18 % at HDT5, p < 0.001) and resistin (+13 % at HDT21, p < 0.001) increased during HDT bed rest. Interestingly, during recovery, YKL-40 levels increased (+13 % at R1, p = 0.022), while MMP-9 levels decreased (-19 % at R6, p = 0.035). We identified correlations between COMP and MMP-3 (r Conclusions: Immobilization affects serum concentrations of cartilage homeostasis biomarkers suggesting changes in cartilage metabolism that do not completely recover during re-ambulation. Both interventions had only minimal effects.
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Registered trials
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