Evidence map›Paper›PMID 40144852›Full record

ArticleJHLT open2025

The state of combined thoracoabdominal triple-organ transplantation in the United States.

Emily G Dunbar, Ye In Christopher Kwon, Matthew Ambrosio, Inna F Tchoukina, Keyur B Shah, David A Bruno, Walker A Julliard, Josue Chery, Vigneshwar Kasirajan, Zubair A Hashmi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emily G DunbarDivision of Cardiothoracic Surgery, Department of Surgery, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia.
Ye In Christopher KwonDivision of Cardiothoracic Surgery, Department of Surgery, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia.
Matthew AmbrosioDepartment of Biostatistics, School of Population Health, Virginia Commonwealth University, Richmond, Virginia.
Inna F TchoukinaDivision of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
Keyur B ShahDivision of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
David A BrunoDivision of Abdominal Transplant Surgery, Department of Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University, Richmond, Virginia.
Walker A JulliardDivision of Cardiothoracic Surgery, Department of Surgery, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia.
Josue CheryDivision of Cardiothoracic Surgery, Department of Surgery, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia.
Vigneshwar KasirajanDivision of Cardiothoracic Surgery, Department of Surgery, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia.
Zubair A HashmiDivision of Cardiothoracic Surgery, Department of Surgery, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: As triple-organ transplantation (TOT) has become more common, we evaluate patient characteristics, risk factors, and clinical outcomes of patients undergoing thoracoabdominal TOT. Methods: This retrospective study utilized data from heart-lung-liver (HLL), heart-lung-kidney (HLK), heart-kidney-liver (HKL), and heart-kidney-pancreas (HKP) recipients from the United Network for Organ Sharing registry between 1989 and 2023. Recipient and donor characteristics and risk factors for mortality were analyzed using Cox regression hazard models. Recipient survival up to 10 years was analyzed using the Kaplan-Meier method. Results: During the study period, 81 TOTs were performed (13 HLLs, 13 HLKs, 46 HKLs, and 9 HKPs). There were no statistically significant differences in long-term survival between TOTs ( Conclusions: The prevalence of TOTs has dramatically increased over the past decade. While overall survival between TOTs appears similar, adding a liver to a heart-lung transplant may be associated with a poorer prognosis compared to adding a kidney. A careful, multidisciplinary approach to patient selection and management remains paramount in optimizing outcomes for high-risk patients undergoing TOTs.

Indexed as

heart-kidney-liver transplantheart-kidney-pancreas transplantheart-liver-lung transplantheart-lung-kidney transplanttriple-organ transplant

Identifiers

PMID40144852
PMCPMC11935415

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.