Evidence map›Paper›PMID 40144843›Full record

ArticleJHLT open2025

Concomitant abdominal organ transplantation alongside lung transplantation: An ISHLT transplant database analysis.

Renita Wilson, J Asher Jenkins, Juan Maria Farina, Blake Langlais, Bashar Aqel, Ashraf Omar, Jonathan D'Cunha, Pedro Reck Dos Santos

Abstract read
In one paragraph

Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Renita WilsonMayo Clinic Alix School of Medicine, Phoenix, Arizona.
J Asher JenkinsDepartment of Cardiothoracic Surgery, Mayo Clinic Arizona, Phoenix, Arizona.
Juan Maria FarinaDepartment of Cardiothoracic Surgery, Mayo Clinic Arizona, Phoenix, Arizona.
Blake LanglaisDivision of Clinical Trials and Biostatistics, Mayo Clinic Arizona, Phoenix, Arizona.
Bashar AqelDivision of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, Arizona.
Ashraf OmarDivision of Transplant Pulmonology, Mayo Clinic Arizona, Phoenix, Arizona.
Jonathan D'CunhaDepartment of Cardiothoracic Surgery, Mayo Clinic Arizona, Phoenix, Arizona.
Pedro Reck Dos SantosDepartment of Cardiothoracic Surgery, Mayo Clinic Arizona, Phoenix, Arizona.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Concomitant abdominal organ transplant of the liver, kidney, and/or pancreas with lung transplant (Con-AbLTx) may be considered for appropriate patients who present with end-stage disease of multiple organ systems. Most existing literature examines outcomes of combined lung-liver transplants, with little attention paid to other commonly transplanted abdominal organs, such as kidneys and pancreas. This study aims to examine post-transplant outcomes of patients submitted to Con-AbLTx to lung transplant (LTx)-only recipients. Methods: The international society for heart and lung transplantation (ISHLT) International Thoracic Organ Transplant Registry for Con-AbLTx and LTx-only was reviewed from January 1994 to June 2018. LTx-only recipients were propensity score matched 4:1 based on various patient characteristics. Data were analyzed with Fisher's exact, Wilcoxon rank sum tests, Kaplan-Meier methods, and Cox proportional hazards where appropriate. Results: A total of 195 Con-AbLTx and 780 propensity-matched LTx-only cases were compared. LTx-only recipients demonstrated higher levels of bronchiolitis obliterans syndrome. Following transplant, Con-AbLTx required a longer hospital stay and post-transplant dialysis before discharge. LTx-only were more likely to experience graft failure from acute rejection or chronic rejection. Con-AbLTx experienced higher 1-year mortality than LTx-only counterparts, with the highest mortality seen in the concomitant lung/kidney group. Of concomitant transplants, lung/liver recipients had greater survival over time. Conclusions: Con-AbLTx has the potential to carry substantial morbidity. At 10 years post-transplant, there is no statistically significant difference in survival between LTx-only and Con-AbLTx recipients. Given limited organ availability and ethical considerations of simultaneous transplant, careful consideration for Con-AbLTx is paramount to achieve acceptable outcomes.

Indexed as

abdominal transplantconcomitant transplantgraft survivallung transplantsimultaneous transplant

Identifiers

PMID40144843
PMCPMC11935321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.