ArticleEuropean heart journal. Case reports2025
First demonstration of implication of hereditary alpha-tryptasaemia in vasospastic angina: a case report.
Article in European heart journal. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Vasospastic angina is a common condition. In cases of poor therapeutic response, less common causes should be explored. Case summary: A 50-year-old woman with vasospastic angina was diagnosed with significant fluctuation in response to treatment without explanation that led to the suspicion of an allergic phenomenon. A diagnosis of hereditary alpha-tryptasaemia was made, and introduction of a second-generation H1-antihistamine has enabled effective control of previously treatment-resistant vasospastic coronary disease. Discussion: The case shows the first time the involvement of hereditary alpha-tryptasaemia in vasospastic angina. Future pathophysiological investigations will be needed to further explore the connection between these two pathologies.
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