Evidence map›Paper›PMID 40144640›Full record

ArticleCell biomaterials2025

Nathaniel P Skillin, Bruce E Kirkpatrick, Nicole E Friend, Amy R Perry, Joselle M McCracken, Melvin Colorado Escobar, Benjamin R Nelson, Nathaniel L Day, Patrick S Hume, Taufiek Konrad Rajab and 2 more

Abstract read
In one paragraph

Article in Cell biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nathaniel P SkillinDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.
Bruce E KirkpatrickDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.
Nicole E FriendDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.
Amy R PerryThe BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Joselle M McCrackenDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.
Melvin Colorado EscobarMaterials Science and Engineering Program, University of Colorado Boulder, Boulder, CO 80303, USA.
Benjamin R NelsonDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.
Nathaniel L DayDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.
Patrick S HumeDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Taufiek Konrad RajabDepartment of Cardiovascular Surgery, Arkansas Children's Hospital, Little Rock, AR 72202, USA.
Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.
Timothy J WhiteDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, USA.

Funding

Osteogenic Hydrogel Niches to Promote hMSC Migration and DifferentiationR01DE016523 · NIDCR · UNIVERSITY OF COLORADO AT BOULDER · PI ANSETH, KRISTI S. · 2005 to 2023
$6.2M
Granular hydrogels for the controlled delivery of immunomodulatory and angiogenic extracellular vesicles to enhance bone tissue regenerationF32AR084876 · NIAMS · UNIVERSITY OF COLORADO · PI Nicole Erin Friend · 2024 to 2026
$228k
Developing near-infrared responsive liquid crystal elastomers for an adjustable pulmonary artery bandF30HL164047 · NHLBI · UNIVERSITY OF COLORADO · PI SKILLIN, NATHANIEL PHILLIP · 2022 to 2025
$172k
NHLBI NIH HHS F30 HL164047NIAMS NIH HHS F32 AR084876NIDCR NIH HHS R01 DE016523
6 · The paper itself

Abstract

Medical implants with fixed geometry have many clinical applications but are limited by the dynamic nature of human physiology. To overcome this barrier, focus has shifted to stimuli-responsive materials capable of changing their geometry on demand, such as liquid crystalline elastomers (LCEs). Here, we report on the development and biological performance of LCE-gold nanorod (LCE-AuNR) nanocomposites engineered for use in optically reconfigurable medical devices. First, we maximized the strain response and force output of 3D-printed LCE-AuNR within a physiologically relevant temperature window of 37°C-50°C. LCE-AuNR are shown to be cytocompatible and induce a comparable foreign body response to medical grade silicone when implanted subcutaneously in mice. Upon transcutaneous near-infrared irradiation, implanted LCE-AuNR exhibit rapid and reversible photothermal actuation. Furthermore, controlled photothermal actuation

Identifiers

PMID40144640
PMCPMC11936506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.