Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study.

Background: Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) may be involved in the inflammatory response and aggravate secondary brain injury after spontaneous intracerebral hemorrhage (sICH). The aim of this study was to reveal the association of serum sLOX-1 levels with disease severity and the predictive power of 90-day neurological outcomes after sICH. Method: This prospective cohort study included 118 sICH patients and 118 healthy controls, whose serum sLOX-1 levels were quantified. Glasgow Coma Scale (GCS) scores and hematoma volumes were used to assess disease severity. Glasgow Outcome Scale (GOS) scores were used to assess 3-month function prognosis after stroke. The relation of serum sLOX-1 levels to disease severity and prognosis (GOS scores 1-3) was discerned Receiver operating characteristic curve was built to evaluate the prognostic predictive capability. Result: Serum sLOX-1 levels were significantly increased in patients compared to healthy controls, and were independently correlated with GCS scores ( Conclusion: Serum sLOX-1 levels are obviously increased after stroke and are significantly associated with disease severity and poor prognosis. Hence, sLOX-1 may serve as a useful potential prognostic biomarker for sICH.