Efficacy of dexamethasone combined with intravenous immunoglobulin for the treatment of pediatric autoimmune encephalitis.

Introduction: Glucocorticoids and intravenous immunoglobulin (IVIG) have been established as the primary therapeutic agents for treating autoimmune encephalitis (AE). Methylprednisolone is the most frequently utilized glucocorticoid; however, the potential advantages of dexamethasone (DEX) in the management of encephalitis have yet to be fully elucidated. This study aimed to assess the efficacy of DEX in combination with IVIG in the treatment of pediatric AE. Methods: This retrospective study included 41 pediatric patients who were diagnosed with AE and were categorized into two groups on the basis of their treatment history. Group A ( Results: Ninety percent of the patients were severely ill prior to DEX+IVIG treatment (mRS = 3.8 ± 1.0). Following treatment, the clinical symptoms of children in both the nonacute stage (Group A) and the acute stage (Group B) significantly improved. At the final follow-up, 90.2% of patients (mRS = 0-2) exhibited a favorable prognosis, with a complete response rate (mRS = 0) of 43.9% and a relapse rate of 2.4%. Children who experienced relapse were treated with DEX+IVIG, leading to a positive outcome. No severe adverse events were observed during treatment. The results of this study indicated that DEX+IVIG is an effective treatment for children with acute, nonacute, and relapsing AE. Discussion: DEX+IVIG was shown to be beneficial at the acute, nonacute, sequelae, and recurrence stages of AE.