Evidence map›Paper›PMID 40144589›Full record

ReviewFrontiers in human neuroscience2025

Neuroplastic effects of transcranial alternating current stimulation (tACS): from mechanisms to clinical trials.

Desmond Agboada, Zhihe Zhao, Miles Wischnewski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Efficacy of transcranial alternating current stimulation on cognitive function in patients with dementia: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  11. Modulation of prefrontal theta oscillations slows social cognition.Cognitive, affective & behavioral neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Desmond AgboadaDepartment of Psychology, University of the Bundeswehr Munich, Neubiberg, Germany.
Zhihe ZhaoDepartment of Biomedical Engineering, University of Minnesota, Twin Cities, MN, United States.
Miles WischnewskiDepartment of Psychology, University of Groningen, Groningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial alternating current stimulation (tACS) is a promising non-invasive neuromodulation technique with the potential for inducing neuroplasticity and enhancing cognitive and clinical outcomes. A unique feature of tACS, compared to other stimulation modalities, is that it modulates brain activity by entraining neural activity and oscillations to an externally applied alternating current. While many studies have focused on online effects during stimulation, growing evidence suggests that tACS can induce sustained after-effects, which emphasizes the potential to induce long-term neurophysiological changes, essential for therapeutic applications. In the first part of this review, we discuss how tACS after-effects could be mediated by four non-mutually exclusive mechanisms. First, spike-timing-dependent plasticity (STDP), where the timing of pre- and postsynaptic spikes strengthens or weakens synaptic connections. Second, spike-phase coupling and oscillation phase as mediators of plasticity. Third, homeostatic plasticity, emphasizing the importance of neural activity to operate within dynamic physiological ranges. Fourth, state-dependent plasticity, which highlights the importance of the current brain state in modulatory effects of tACS. In the second part of this review, we discuss tACS applications in clinical trials targeting neurological and psychiatric disorders, including major depressive disorder, schizophrenia, Parkinson's disease, and Alzheimer's disease. Evidence suggests that repeated tACS sessions, optimized for individual oscillatory frequencies and combined with behavioral interventions, may result in lasting effects and enhance therapeutic outcomes. However, critical challenges remain, including the need for personalized dosing, improved current modeling, and systematic investigation of long-term effects. In conclusion, this review highlights the mechanisms and translational potential of tACS, emphasizing the importance of bridging basic neuroscience and clinical research to optimize its use as a therapeutic tool.

Indexed as

clinical trialslong-term effectsneuroplasticityrepeated stimulationtACS (transcranial alternating current stimulation)

Identifiers

PMID40144589
PMCPMC11936966

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.