Evidence map›Paper›PMID 40144583›Full record

ArticleJHLT open2023

Incidence and severity of SARS-CoV-2 infection in lung transplant recipients in the Omicron era.

Neval Ete Wareham, Sebastian Rask Hamm, Regitze Hertz Liebermann, Dina Leth Møller, Laurids Brandt Laursen-Keldorff, Andreas Runge Poulsen, Thomas Kromann Lund, Kristine Jensen, Hans Henrik L Schultz, Michael Perch and 1 more

Abstract read
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Article in JHLT open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Neval Ete WarehamDepartment of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Sebastian Rask HammDepartment of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Regitze Hertz LiebermannDepartment of Cardiology, Section for Lung Transplantation, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Dina Leth MøllerDepartment of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Laurids Brandt Laursen-KeldorffDepartment of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Andreas Runge PoulsenDepartment of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Thomas Kromann LundDepartment of Cardiology, Section for Lung Transplantation, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Kristine JensenDepartment of Cardiology, Section for Lung Transplantation, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Hans Henrik L SchultzDepartment of Cardiology, Section for Lung Transplantation, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Michael PerchDepartment of Cardiology, Section for Lung Transplantation, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Susanne Dam NielsenDepartment of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may cause serious illness in lung transplant recipients. We aimed to investigate incidence and severity of SARS-CoV-2 infection in lung transplant recipients in the Omicron era. We conducted a retrospective study investigating COVID-19 incidence and outcomes among lung transplant recipients between December 27, 2021, and October 31, 2022, in Denmark. We performed COX regression analysis of potential risk factors with hospitalization as an endpoint. Among 236 included patients, 108 had a first positive SARS-CoV-2 polymerase chain reaction during a total of 133 person-years of follow-up, resulting in an incidence rate of 813 per 1000 person-years (95% confidence intervals (CI) 670-977). The cumulative incidence of hospitalization was 24.1% (95% CI 26-32.1) and admission to the intensive care unit was 3.7% (95% CI 0.1-6.3). The 30-day mortality of recipients with a SARS-CoV-2 infection was 0.9% (95% CI 0-2.7). We found that the incidence rate of patients with SARS-CoV-2 infection was markedly higher, whereas the mortality rate was lower in the omicron era compared to earlier reports for lung transplant recipients conducted in the delta era. On the other hand, a substantial proportion of patients were hospitalized, suggesting a continuous impact on this patient population.

Indexed as

COVID-19lung transplantationOmicronSARS-CoV-2

Identifiers

PMID40144583
PMCPMC11935381

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.