ReviewFrontiers in physiology2025
Circadian system coordination: new perspectives beyond classical models.
Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This review examines novel interaction mechanisms contributing to the robustness of circadian rhythms, focusing on enhanced communication between the suprachiasmatic nucleus (SCN) and peripheral clocks. While classical models explain biological clocks through molecular interactions and biochemical signaling, they incompletely account for several key features: precision maintenance despite cellular noise, rapid system-wide synchronization, and temperature compensation. We propose that the SCN, acting as a central hub, may utilize non-classical mechanisms to maintain robust synchronization of peripheral clocks, contributing to biological timekeeping stability. The clinical implications of this model are significant, potentially offering new approaches for treating circadian-related disorders through quantum-based interventions. Recent advances in quantum biosensors and diagnostic tools show promise for early detection and monitoring of circadian disruptions, while quantum-based therapeutic strategies may provide novel treatments for conditions ranging from sleep disorders to metabolic syndromes. Aim of review: To evaluate classical models of circadian rhythm robustness and propose a novel synchronization model incorporating quantum mechanical principles, supported by recent advances in quantum biology and chronobiology, with emphasis on potential clinical applications. Key scientific concepts: Recent research in quantum biology suggests potential mechanisms for enhanced circadian system coordination. The proposed model explores how quantum effects, including entanglement and coherence, may facilitate rapid system-wide synchronization and temporal coherence across tissues. These mechanisms could explain features not fully addressed by classical models: precision maintenance in noisy cellular environments, rapid resynchronization following environmental changes, temperature compensation of circadian periods, and sensitivity to weak electromagnetic fields. The framework integrates established chronobiology with quantum biological principles to explain system-wide temporal coordination and suggests new therapeutic approaches for circadian-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.