ArticleFrontiers in physiology2025
Peripheral vasoconstriction is not elevated during hyperreactive responses to the cold pressor test: a cross-sectional study.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Individuals demonstrating increases in systolic systolic blood pressure or diastolic diastolic blood pressure blood pressure of at least 15 mmHg are considered hyperreactors to the cold pressor test (CPT). However, it remains unclear if peripheral vasoconstriction is similarly exaggerated during the CPT in these individuals. Methods: Fifty-five individuals (54.5% non-White, 67.3% female) performed a single-visit study including a 2-min CPT of the foot, a 2-min bout of rhythmic handgrip exercise ([HG] 25% maximal voluntary contraction), and a 2-min combined trial (CPT + HG). Beat-by-beat heart rate (HR), blood pressure, and forearm blood flow (FBF) were continuously recorded, and vascular conductance (FVC) was calculated as FBF/mean arterial pressure (MAP). Results: Hyperreactors ( Conclusion: These findings indicate that hyperreactive blood pressure responses to the CPT are not accompanied by increased peripheral vasoconstriction. Moreover, handgrip exercise attenuates hyperreactive blood pressure responses to the CPT.
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