Evidence map›Paper›PMID 40144424›Full record

ArticleCureus2025

Atypical Electrophysiological Pattern in Hypokalemic Periodic Paralysis With CACNA1S Mutation: A Case Report.

Kamal Haddouali, Hajar El Omari, Hicham El Otmani, Bouchra El Moutawakil, Mohammed Abdoh Rafai

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kamal HaddoualiResearch Laboratory on Diseases of the Nervous System, Neurosensory and Handicap, Hassan II University, Faculty of Medicine and Pharmacy, Casablanca, MAR.
Hajar El OmariDepartment of Neurology and Neurophysiological Explorations, Ibn Rochd University Hospital - Hassan II University, Faculty of Medicine and Pharmacy, Casablanca, MAR.
Hicham El OtmaniDepartment of Neurology and Neurophysiological Explorations, Ibn Rochd University Hospital - Hassan II University, Faculty of Medicine and Pharmacy, Casablanca, MAR.
Bouchra El MoutawakilDepartment of Neurology and Neurophysiological Explorations, Ibn Rochd University Hospital - Hassan II University, Faculty of Medicine and Pharmacy, Casablanca, MAR.
Mohammed Abdoh RafaiDepartment of Neurology and Neurophysiological Explorations, Ibn Rochd University Hospital - Hassan II University, Faculty of Medicine and Pharmacy, Casablanca, MAR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypokalemic periodic paralysis type 1 (PPHy-1) is a rare autosomal dominant disorder caused by mutations in the CACNA1S gene, leading to recurrent muscle weakness associated with hypokalemia. We describe a 19-year-old male presenting with recurrent episodes of muscle weakness lasting from 2 to 48 hours. During an attack, clinical examination revealed tetraparesis with axial motor deficits, but no bulbar or facial involvement. Serum potassium levels were 2.5 mmol/L, and nerve conduction studies (NCS) showed asymmetrical decrement in motor amplitudes. A long exercise test (LET) post-attack revealed pattern IV, an atypical finding for PPHy-1. Whole exome sequencing confirmed a heterozygous mutation in the

Indexed as

cacna1scalcium channelchannelopathylong exercise testperiodic paralysis

Identifiers

PMID40144424
PMCPMC11937951

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Registered trials

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