Evidence map›Paper›PMID 40144331›Full record

ArticleNature chemical engineering2025

Self-aggregating long-acting injectable microcrystals.

Vivian R Feig, Sanghyun Park, Pier Giuseppe Rivano, Jinhee Kim, Benjamin Muller, Ashka Patel, Caroline Dial, Sofia Gonzalez, Hannah Carlisle, Flavia Codreanu and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Vivian R Feig *Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Sanghyun Park *Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.ORCID 0000-0002-4336-2621
Pier Giuseppe Rivano *Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.ORCID 0009-0005-9568-7291
Jinhee KimDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Benjamin MullerDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Ashka PatelDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Caroline DialDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Sofia GonzalezDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Hannah CarlisleDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Flavia CodreanuDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Aaron LopesDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Ayten E ErdoganDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Niora FabianKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA USA.
Ashley GuevaraKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA USA.
Andrew PettinariKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA USA.
Jason LiDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Jia LiangDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Gary W LiuKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA USA.
Mark W TibbittMacromolecular Engineering Laboratory, ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-4917-7187
Giovanni TraversoDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.ORCID 0000-0001-7851-4077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injectable drug depots have transformed our capacity to enhance medication adherence through dose simplification. Central to patient adoption of injectables is the acceptability of needle injections, with needle gauge as a key factor informing patient discomfort. Maximizing drug loading in injectables supports longer drug release while reducing injection volume and discomfort. Here, to address these requirements, we developed self-aggregating long-acting injectable microcrystals (SLIM), an injectable formulation containing drug microcrystals that self-aggregate in the subcutaneous space to form a monolithic implant with a low ratio of polymer excipient to drug (0.0625:1 w/w). By minimizing polymer content, SLIM supports injection through low-profile needles (<25 G) with high drug loading (293 mg ml

Indexed as

Drug deliveryMaterials for devices

Identifiers

PMID40144331
PMCPMC11932925

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.