ArticleEnvironment & health (Washington, D.C.)2025
Impacts of Gestational F-53B Exposure on Fetal Neurodevelopment: Insights from Placental and Thyroid Hormone Disruption.
Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Early Life Exposure to PFOS or F‑53B is Associated with Increased Asthma Susceptibility in Offspring and Alterations in the Pulmonary Barrier, Immune Function, and Gut Microbiota.Environment & health (Washington, D.C.) · 2026Article
- Insights into the Neurotoxicology of Traditional and Emerging Per- and Polyfluoroalkyl Substances: Mechanisms and Research Frontiers.Environment & health (Washington, D.C.) · 2026Review
- Prenatal PFAS exposure and offspring health: evidence review and implications for intergenerational risk assessment.Frontiers in public health · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been evidenced that chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) have strong potential cross the placental barrier, but their adverse effects on offspring remain unclear. In this study, pregnant mice received daily intraperitoneal injections of chlorinated polyfluorinated ether sulfonate (Cl-PFESA; commercially known as F-53B, primarily comprising 6:2 Cl-PFESA and 8:2 Cl-PFESA) at dosages of 40 and 200 μg/kg from gestational days 6 to 17. Following gestational exposure, distinct accumulation of 6:2 and 8:2 Cl-PFESAs was observed in both the placenta and fetal brain, confirming their penetration across the placental and fetal blood-brain barriers. Maternal exposure to F-53B disrupted the placental 11β-hydroxysteroid dehydrogenase type 2 (
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.